Table 3.
Determination of the association between presence of BCa and CXCR4 orCXCR7 transcript levels in exfoliated urothelial cells. A: Univariate analysis. The cut-off limit generated by the ROC curve was used to determine the sensitivity and specificity and accuracy of CXCR7 to detect BCa; in each column mean±sd and 95% CI values obtained by cross-validation (boot-strap modeling; specific sampling rate = 0.5; re-sampling = 104) are shown. B: Analysis of sensitivity by tumor grade and of specificity by non-BCa conditions. BGU category also included 8 patients with HX of other urologic cancers.
| Table 3 A
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|---|---|---|---|---|---|---|---|---|
| Biomarker | Chi- square | P-value | Odds Ratio; 95% CI | AUC | Cut-off | Sensitivity | Specificity | Accuracy |
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| CXCR4 | 1.77 | 0.18 | ND | 0.53 | ND | ND | ND | ND |
|
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| CXCR7 | 16.053 | 0.0001 | 6.4; 2.7 – 16.8 | 0.787 | 0.52 | 80.7% (46/57) 79.5 ± 5.0; 78.5 – 80.5 |
75% (90/120) 75.5 ± 5.0 74.5 – 76.5 |
76.8% 77.5 – 3.9; 76.7 – 78.3 |
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| Table 3B
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| CXCR7 | Sensitivity | Specificity | Other Cancer (% above the cut-off limit) | |||||
| LG | HG | Normal | HXBCa | BGU | ||||
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| 58.8% (10/17) | 90% 36/40) | 92.6% (25/27) | 76.7% (23/30) | 66.7% (42/63) | 66.7% (6/9) | |||