Abstract
Unfractionated human leukocyte interferon, as well as highly purified subspecies of this interferon, and a purified recombinant of human leukocyte interferon produced in bacteria are active in suppressing multiplicability of tobacco mosaic virus in tobacco leaf discs. Human fibroblast interferon exhibits diverse levels of antiviral activity against tobacco mosaic virus but becomes as active as human leukocyte interferon upon incubation with glycosidases. The effect of interferon is reversible; normal multiplication of tobacco mosaic virus resumes upon removal of interferon.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Clark M. F., Adams A. N. Characteristics of the microplate method of enzyme-linked immunosorbent assay for the detection of plant viruses. J Gen Virol. 1977 Mar;34(3):475–483. doi: 10.1099/0022-1317-34-3-475. [DOI] [PubMed] [Google Scholar]
- Cuatrecasas P. Affinity chromatography. Annu Rev Biochem. 1971;40:259–278. doi: 10.1146/annurev.bi.40.070171.001355. [DOI] [PubMed] [Google Scholar]
- Hobb D. S., Moschera J. A., Levy W. P., Pestka S. Purification of interferon produced in a culture of human granulocytes. Methods Enzymol. 1981;78(Pt A):472–481. doi: 10.1016/0076-6879(81)78158-8. [DOI] [PubMed] [Google Scholar]
- Levy W. P., Rubinstein M., Shively J., Del Valle U., Lai C. Y., Moschera J., Brink L., Gerber L., Stein S., Pestka S. Amino acid sequence of a human leukocyte interferon. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6186–6190. doi: 10.1073/pnas.78.10.6186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muramatsu T., Egami F. Alpha-mannosidase and beta-mannosidase from the liver of Tubo cortunus: purfication, properties and application of carbohydrate research. J Biochem. 1967 Dec;62(6):700–709. doi: 10.1093/oxfordjournals.jbchem.a128726. [DOI] [PubMed] [Google Scholar]
- Rubinstein M., Levy W. P., Moschera J. A., Lai C. Y., Hershberg R. D., Bartlett R. T., Pestka S. Human leukocyte interferon: isolation and characterization of several molecular forms. Arch Biochem Biophys. 1981 Aug;210(1):307–318. doi: 10.1016/0003-9861(81)90194-6. [DOI] [PubMed] [Google Scholar]
- Rubinstein M., Rubinstein S., Familletti P. C., Miller R. S., Waldman A. A., Pestka S. Human leukocyte interferon: production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci U S A. 1979 Feb;76(2):640–644. doi: 10.1073/pnas.76.2.640. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sela I. Plant-virus interactions related to resistance and localization of viral infections. Adv Virus Res. 1981;26:201–237. doi: 10.1016/s0065-3527(08)60424-8. [DOI] [PubMed] [Google Scholar]
- Staehelin T., Hobbs D. S., Kung H., Lai C. Y., Pestka S. Purification and characterization of recombinant human leukocyte interferon (IFLrA) with monoclonal antibodies. J Biol Chem. 1981 Sep 25;256(18):9750–9754. [PubMed] [Google Scholar]
- Stein S., Kenny C., Friesen H. J., Shively J., Del Valle U., Pestka S. NH2-terminal amino acid sequence of human fibroblast interferon. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5716–5719. doi: 10.1073/pnas.77.10.5716. [DOI] [PMC free article] [PubMed] [Google Scholar]