Table 4.

Independent risk of iron phenotype and HFE genotype for advanced histologic features of NAFLD and diagnosis of NASH

Phenotype	OR	95% Conf. Int.	P value
Steatosis Grade 3
H63D mutation	1.74	1.19 – 2.55	0.005
Lob. Inflammation Grade ≥2
H63D mutation	1.45	1.02 – 2.07	0.040
Hep. Ballooning Grade 2
HC iron positive	0.59	0.39 – 0.88	0.011
NAS ≥5
HC iron positive	0.50	0.33 – 0.76	0.001
H63D mutation	1.44	1.01 – 2.06	0.045
Definitive NASH
HC iron positive	0.69	0.46 – 1.00	0.048

HC iron phenotype and HFE genotype was modeled individually including variables any HFE (Y/N) and any HC iron (Y/N), respectively. Each model included potential confounding variables age, sex, BMI, ALT, HOMA-IR and presence of diabetes