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. Author manuscript; available in PMC: 2012 Oct 3.
Published in final edited form as: Neuroscience. 2009 Feb 11;159(4):1414–1421. doi: 10.1016/j.neuroscience.2009.02.006

Figure 5.

Figure 5

Intrathecal injection of OX1R antagonist SB-334867blocked PH-induced antinociception in CCI rats. Following a baseline measurement at −15 min, carbachol (125 nmol) was injected into the PH and three foot withdrawal latencies were taken at −10, −5 and −1 minute. At time 0, the OX1R antagonist, SB-334867 (15, 30, or 60 nmol; closed triangles, squares, and diamonds, respectively; n = 5/group), was injected intrathecally. All three dose of SB-334867 produced a significant decrease in foot withdrawal latencies as compared to DMSO controls (open circles). Symbols equal the mean ± SEM. Standard error bars may be obscured by the symbol.