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. 1982 May;79(10):3265–3269. doi: 10.1073/pnas.79.10.3265

Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines.

T Y Basham, M F Bourgeade, A A Creasey, T C Merigan
PMCID: PMC346396  PMID: 6179079

Abstract

We report that human leukocyte interferon preparations increase the expression of beta 2-microglobulin by 100-200% on the surface of normal fibroblast and melanoma cell lines sensitive to interferon. This increase in expression can be correlated with an increase in HLA synthesis as measured by incorporation of [35S]methionine in these antigens. This enhanced HLA synthesis, which is 5- to 17-fold, is time dependent and dose related. Synchronized cells in the G0/G1 phase of the cell cycle appear to be more sensitive to this interferon action. Neither an increase in surface expression nor in HLA synthesis is observed in a melanoma cell line resistant to the antiviral and antigrowth effects of interferon. Furthermore, there appears to be a stronger correlation between this increased HLA synthesis and the antiviral function than between it and the antiproliferative action of interferon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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