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. 1982 May;79(10):3350–3354. doi: 10.1073/pnas.79.10.3350

Calcium alters the sensitivity of intact horizontal cells to dopamine antagonists.

R Van Buskirk, J E Dowling
PMCID: PMC346413  PMID: 6179080

Abstract

Horizontal cells of the carp retina possess dopamine receptors linked to adenylate cyclase. Isolated, intact horizontal cells respond to micromolar concentrations of dopamine, whereas nanomolar concentrations of haloperidol, (+)-butaclamol, and flupenthixol block the dopamine response. Preincubation in Ringer's solution containing increased levels of Ca2+ (5-110 mM) decreases the sensitivity of the cells to these antagonists by 1,000-10,000 times. Dopamine sensitivity of the cells is not affected by Ca2+ levels in the preincubation medium. Preincubation of the cells in Ringer's solution containing 500 microM L-glutamate, an agent that increases intracellular Ca2+ levels in intact horizontal cells, also decreases the sensitivity of the cells to haloperidol. These data suggest that antagonist sensitivity of intact horizontal cells may be regulated by intracellular Ca2+.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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