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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cancer. 2011 Apr 14;117(21):4925–4938. doi: 10.1002/cncr.26116

Table 2. KEEG Pathway analysis of genetic aberrations in osteosarcoma.

KEEG pathways Gain P value Deletion P value
1. VEGF signaling pathway 0.000612 0.994021
2. Tight junction 0.044333 0.719851
3. mTOR signaling pathway 0.024894 0.676616
4. Hedgehog signaling pathway 0.609822 0.012811
5. Cell adhesion molecules (CAMs) 0.630 0.05
6. Adherens junction 0.119062 0.014329
7. Wnt signaling pathway 0.81461 0.01039
8. alpha-Linolenic acid metabolism 0.003363 1
9. Asthma 0.003038 1
10. Ether lipid metabolism 0.006548 1
11. Nitrogen metabolism 0.007842 0.48671
12. Peptidoglycan biosynthesis 0.017208 1
13. Synthesis and degradation of ketone bodies 0.019871 1
14. Alzheimer's disease 0.020851 0.290129
15. Biosynthesis of unsaturated fatty acids 0.021314 0.198297
16. Arachidonic acid metabolism 0.022277 0.323251
17. Systemic lupus erythematosus 2.49E-06 0.997392
18. Glycan structures-biosynthesis 2 0.025972 0.806243
19. Antigen processing and presentation 0.028228 0.984565
20. C21-Steroid hormone metabolism 0.042216 0.166058
21. Fc epsilon RI signaling pathway 0.000481 0.899467
22. Allograft rejection 0.046891 0.250208
23. Insulin signaling pathway 0.047775 0.331333
24. GnRH signaling pathway 0.048738 0.812648
25. PPAR signaling pathway 0.052305 0.039963
26. ECM-receptor interaction 0.457871 0.032505
27. T cell receptor signaling pathway 0.539028 0.020903
28. Non-homologous end-joining 0.552678 0.001607
29. Phosphatidylinositol signaling system 0.714791 0.040426
30. Melanogenesis 0.960398 0.007761
31. Basal cell carcinoma 0.978857 0.00088
32. Metabolism of xenobiotics by cytochrome P450 0.999938 0.006437
33. Monoterpenoid biosynthesis 1 0.004507