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. 1982 Jul;79(13):3958–3962. doi: 10.1073/pnas.79.13.3958

Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide.

M L Privalsky, J M Bishop
PMCID: PMC346555  PMID: 6287456

Abstract

Avian erythroblastosis virus (AEV) induces erythroblastosis and sarcomas in chickens. Two domains within the viral genome, erb-A and erb-B, have been implicated in AEV-mediated oncogenesis. By use of hybridization-arrested translations and hybridization-selections of mRNA, we have mapped on the viral genome the polypeptides specified by the erb domains. The results of hybridization-arrest with DNA representing the spliced 5' leader region of the AEV mRNA suggested that the authentic product of the erb-B domain was a 61,000 molecular weight protein, not a 41,000 molecular weight polypeptide previously identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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