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. 1982 Jul;79(13):4153–4155. doi: 10.1073/pnas.79.13.4153

Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.

D Faustman, V Hauptfeld, P Lacy, J Davie
PMCID: PMC346595  PMID: 6810361

Abstract

Streptozotocin-induced diabetes in mice can be reversed by transplantation of islets of Langerhans from histoincompatible mice if the islets are treated with anti-Ia-serum and complement before transplantation. Here we show that anti-Ia-treated islets most likely induce tolerance in the recipient animals. Daily injections of recipient-specific anti-I-J-serum (beginning 80 or more days after transplantation) and small numbers of donor splenocytes caused the prompt rejection of the islets in half of the animals; neither anti-I-J-serum nor donor splenocytes alone were effective. It is likely that rejection of established allografts after this treatment is the result of abolition of the activity of allograft-specific suppressor cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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