Abstract
Two to 30 days after complete isolation of the cerebellar cortex of adult rats, small Golgi II type neurons in the granular layer develop presynaptic sites on their dendrites and perikarya. The newly developed presynaptic dendrites established dendrodendritic synaptic contacts with dendritic digits of granule cells. In addition, some granule cells were observed to develop presynaptic sites on their somata and dendritic digits, resulting in the formation of (sometimes reciprocal) dendrodendritic synapses between granule cells or between granule cells and Golgi neurons. The development of these unusual synaptic formations indicates a persisting synaptic plasticity of these two cerebellar cell types. It is suggested that this unorthodox synapse formation develops as part of a reactive compensatory process to synaptic desaturation brought about by the deafferentation of the cerebellum.
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- Hámori J., Lakos I., Mezey E. Myelinated dendrites of Purkinje cells in deafferented cerebellar cortex. J Hirnforsch. 1980;21(4):391–407. [PubMed] [Google Scholar]
- Hámori J., Lakos I. Ultrastructural alterations in the initial segments and in the recurrent collateral terminals of Purkinje cells following axotomy. Cell Tissue Res. 1980;212(3):415–427. doi: 10.1007/BF00236507. [DOI] [PubMed] [Google Scholar]
- Hámori J., Mezey E. Serial and triadic synapses in the cerebellar nuclei of the cat. Exp Brain Res. 1977 Nov 24;30(2-3):259–273. doi: 10.1007/BF00237255. [DOI] [PubMed] [Google Scholar]
- Hámori J., Mezey E., Szentágothai J. Electron microscopic identification of cerebellar nucleo-cortical mossy terminals in the rat. Exp Brain Res. 1981;44(1):97–100. doi: 10.1007/BF00238753. [DOI] [PubMed] [Google Scholar]
- Hámori J., Szentágothai J. The Purkinje cell baskets: ultrastructure of an inhibitory synapse. Acta Biol Acad Sci Hung. 1965;15(4):465–479. [PubMed] [Google Scholar]
- Kim S. U. Granule cell with somatodendritic synapse in organotypic cultures of mouse cerebellum. Exp Neurol. 1974 Dec;45(3):659–662. doi: 10.1016/0014-4886(74)90167-8. [DOI] [PubMed] [Google Scholar]
- Mariani J., Crepel F., Mikoshiba K., Changeux J. P., Sotelo C. Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse. Philos Trans R Soc Lond B Biol Sci. 1977 Nov 2;281(978):1–28. doi: 10.1098/rstb.1977.0121. [DOI] [PubMed] [Google Scholar]
- Raisman G., Field P. M. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei. Brain Res. 1973 Feb 28;50(2):241–264. doi: 10.1016/0006-8993(73)90729-4. [DOI] [PubMed] [Google Scholar]
- Sloper J. J. Dendro-dendritic synapses in the primate motor cortex. Brain Res. 1971 Nov;34(1):186–192. doi: 10.1016/0006-8993(71)90361-1. [DOI] [PubMed] [Google Scholar]
- Somogyi P., Hámori J. A quantitative electron microscopic study of the Purkinje cell axon initial segment. Neuroscience. 1976;1(5):361–365. doi: 10.1016/0306-4522(76)90127-5. [DOI] [PubMed] [Google Scholar]
- Sotelo C. Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse. Brain Res. 1975 Aug 22;94(1):19–44. doi: 10.1016/0006-8993(75)90874-4. [DOI] [PubMed] [Google Scholar]
- Sotelo C. Formation of presynaptic dendrites in the rat cerebellum following neonatal X-irradiation. Neuroscience. 1977;2(2):275–283. doi: 10.1016/0306-4522(77)90094-x. [DOI] [PubMed] [Google Scholar]
- Sotelo C. Purkinje cell ontogeny: formation and maintenance of spines. Prog Brain Res. 1978;48:149–170. doi: 10.1016/S0079-6123(08)61021-3. [DOI] [PubMed] [Google Scholar]