Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1982 Sep;79(17):5367–5369. doi: 10.1073/pnas.79.17.5367

Genetic instability in Drosophila melanogaster: deletion induction by insertion sequences.

M M Green
PMCID: PMC346897  PMID: 6291042

Abstract

Females of Drosophila melanogaster heteroallelic or homoallelic for X chromosome giant (gt) mutants generate deletions involving the wild-type alleles at two X chromosome gene loci: yellow body color (y) and white eye color (w). The deletions, bidirectional in the case of y and with fixed endpoint in the case of w, are associated with particular X chromosomes. Distinctive insertion sequences, located proximal to the target loci, are presumed to generate the deletions.

Full text

PDF
5367

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ananiev E. V., Gvozdev V. A., Ilyin Yu V., Tchurikov N. A., Georgiev G. P. Reiterated genes with varying location in intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes. Chromosoma. 1978 Dec 21;70(1):1–17. doi: 10.1007/BF00292211. [DOI] [PubMed] [Google Scholar]
  2. Ananiev E. V., Gvozdev V. A., Ilyin Yu V., Tchurikov N. A., Georgiev G. P. Reiterated genes with varying location in intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes. Chromosoma. 1978 Dec 21;70(1):1–17. doi: 10.1007/BF00292211. [DOI] [PubMed] [Google Scholar]
  3. Bingham P. M., Judd B. H. A copy of the copia transposable element is very tightly linked to the Wa allele at the white locus of D. melanogaster. Cell. 1981 Sep;25(3):705–711. doi: 10.1016/0092-8674(81)90177-x. [DOI] [PubMed] [Google Scholar]
  4. Calos M. P., Miller J. H. Transposable elements. Cell. 1980 Jul;20(3):579–595. doi: 10.1016/0092-8674(80)90305-0. [DOI] [PubMed] [Google Scholar]
  5. Dowsett A. P., Young M. W. Differing levels of dispersed repetitive DNA among closely related species of Drosophila. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4570–4574. doi: 10.1073/pnas.79.15.4570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Habermann P., Starlinger P. Bidirectional deletions associated with IS4. Mol Gen Genet. 1982;185(2):216–222. doi: 10.1007/BF00330790. [DOI] [PubMed] [Google Scholar]
  7. Lefevre G. The distribution of randomly recovered X-ray-induced sex-linked genetic effects in Drosophila melanogaster. Genetics. 1981 Nov-Dec;99(3-4):461–480. doi: 10.1093/genetics/99.3-4.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Reif H. J., Saedler H. IS1 is involved in deletion formation in the gal region of E. coli K12. Mol Gen Genet. 1975;137(1):17–28. doi: 10.1007/BF00332538. [DOI] [PubMed] [Google Scholar]
  9. Starlinger P. IS elements and transposons. Plasmid. 1980 May;3(3):241–259. doi: 10.1016/0147-619x(80)90039-6. [DOI] [PubMed] [Google Scholar]
  10. Strobel E., Dunsmuir P., Rubin G. M. Polymorphisms in the chromosomal locations of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell. 1979 Jun;17(2):429–439. doi: 10.1016/0092-8674(79)90169-7. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES