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. 1982 Sep;79(17):5411–5414. doi: 10.1073/pnas.79.17.5411

Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.

C B Huggins, L Grand, N Ueda
PMCID: PMC346907  PMID: 6813859

Abstract

The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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