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The Journal of Pediatric Pharmacology and Therapeutics : JPPT logoLink to The Journal of Pediatric Pharmacology and Therapeutics : JPPT
. 2004 Apr-Jun;9(2):96–103. doi: 10.5863/1551-6776-9.2.96

Development of Gastrointestinal Function: Risk Factors for Necrotizing Enterocolitis

David A Clark 1,, Amy L Mitchell 1
PMCID: PMC3469134  PMID: 23118695

Abstract

The intestinal tract of the fetus matures rapidly in the third trimester of the pregnancy. The premature infant has decreased intestinal motility, limited digestion, absorption and excretion, and poor intestinal barrier defense. These limitations place the infant at high risk for acute intestinal injury, necrotizing enterocolitis. This article reviews the development of the gastrointestinal tract in the fetus, the barriers to feeding the high risk, premature infant, and the most serious intestinal disease, necrotizing enterocolitis.

Keywords: gastrointestinal tract, necrotizing enterocolitis, prematurity

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