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The Journal of Pediatric Pharmacology and Therapeutics : JPPT logoLink to The Journal of Pediatric Pharmacology and Therapeutics : JPPT
. 2004 Jan-Mar;9(1):49–54. doi: 10.5863/1551-6776-9.1.49

Methemoglobinemia Associated with Metoclopramide Therapy in a Neonate

Kristine G Palmer 1,, Laura P James 1
PMCID: PMC3469149  PMID: 23118691

Abstract

With the removal of cisapride from the U.S. market, practitioners have increasingly used other medications, such as metoclopramide, to treat gastroesophageal reflux in pediatric patients. We describe the case of a neonate who developed methemoglobinemia after receiving metoclopramide at doses slightly above the recommended age-appropriate dosage. Health care providers should be aware of this potentially serious side effect in young infants who receive this medication.

Keywords: methemoglobinemia, metoclopramide, neonate

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