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. 1982 Sep;79(18):5490–5493. doi: 10.1073/pnas.79.18.5490

Stability of carbohydrate-modified vesicles in vivo: comparative effects of ceramide and cholesterol glycoconjugates.

P S Wu, H M Wu, G W Tin, J R Schuh, W R Croasmun, J D Baldeschwieler, T Y Shen, M M Ponpipom
PMCID: PMC346929  PMID: 6957877

Abstract

The stability and tissue distribution of lipid vesicles modified at the surface by the incorporation of either a galactosyl ceramide (GalCer) or a galactosyl cholesterol (GalChol) glycoconjugate have been studied in mice by measuring the release of vesicle-entrapped 111In. Although the tissue distributions of both vesicle types were similar, the GalCer-containing vesicles were markedly less stable than those prepared with GalChol, whether administered orally or by intraperitoneal injection. Physical characterization of the vesicles in vitro suggests that the increased disruption rate for GalCer vesicles in vivo is related to structural instabilities induced by the cerebroside, which can then result in either an increased rate of vesicle uptake by tissues or a greater susceptibility to lysis. These studies demonstrate the importance of the nonpolar anchoring groups in determining the fate of surface-modified vesicles in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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