Table 4. Correlates of LINE-1 DNA methylation in 568 school-age children from Bogotá, Colombia.
| |
Adjusted %5mC difference1 |
|---|---|
| β (95% CI) | |
| Sex |
|
| Male |
Reference |
| Female |
-0.21 (-0.32, -0.09) |
| P |
0.0007 |
| Plasma vitamin A, μmol/L |
|
| < 0.700 |
Reference |
| 0.700 - 1.049 |
-0.07 (-0.24, 0.10) |
| ≥ 1.050 |
-0.19 (-0.36, -0.02) |
| P trend2 |
0.006 |
| C-reactive Protein, mg/L |
|
| < 1.0 |
Reference |
| ≥ 1.0 |
-0.12 (-0.24, -0.01) |
| P |
0.04 |
| Maternal BMI, kg/m2 |
|
| < 18.5 |
Reference |
| ≥ 18.5 |
0.31 (0.01, 0.60) |
| P |
0.04 |
| Household Socioeconomic Stratum3 |
|
| 1–3 (lower) |
Reference |
| 4 (highest) |
0.29 (0.07, 0.51) |
| P | 0.01 |
1From a linear regression model with LINE-1 DNA methylation as the outcome and predictors that included sex, vitamin A, CRP, maternal BMI, and household socioeconomic stratum. 2Test for linear trend from a linear regression model where an ordinal indicator for the variable was entered as a continuous predictor. 3According to the local government classification.