Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 1;7(10):1142–1150. doi: 10.4161/epi.21937

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

PMC Copyright notice

graphic file with name epi-7-1142-g6.jpg — Figure 6. Schematic representation of the chromosome 14q32.2 imprinted region in a control subject, cases 1 and 2 with upd(14)pat, case 3 with a microdeletion (indicated by stippled rectangles), and case 4 with two copies of the imprinted region of paternal origin and a single copy of the imprinted region of maternal origin. This figure has been constructed using the present results and the previous data.²^,³ P, paternally derived chromosome; M, maternally derived chromosome. Filled and open circles represent hypermethylated and hypomethylated DMRs, respectively; since the MEG3-DMR is grossly hypomethylated and regarded as non-DMR in the placenta, it is painted in gray. PEGs (DLK1 and RTL1) are shown in blue, MEGs (MEG3, RTL1as, MEG8, snoRNAs and miRNAs) in red, a probably non-imprinted gene (DIO3) in black, and non-expressed genes in white. Thick arrows for RTL1 in cases 1–3 represent increased RTL1 expression that is ascribed to loss of functional microRNA-containing RTL1as as a repressor for RTL1.