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. 1982 Nov;79(22):7004–7008. doi: 10.1073/pnas.79.22.7004

Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line.

C H Uittenbogaart, J L Fahey
PMCID: PMC347263  PMID: 6983693

Abstract

A growth factor was found in the supernatants of MOLT-4f, a cell line derived from acute T lymphoblastic leukemia. This factor, which we designated leukemia-derived growth factor from MOLT-4f (LDGF-M4), is different from interleukin 2. LDGF-M4 has features of a polypeptide with a molecular weight in the range of 5,000-15,000, as indicated by gel diffusion chromatography. LDGF-M4 does stimulate MOLT-4f and at least two other T cell lines that do not respond to interleukin 2. Because MOLT-4f cells produce and respond to LDGF-M4, this factor may contribute to the independence of MOLT-4f and related T leukemia cell lines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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