Abstract
Cell types present in the mammary gland and their evolution were studied by labeling female rats with radioactive thymidine at various phases of the estrus cycle. The results suggest that the stem cells for mammary development are present in the terminal end buds and that they generate a lineage for lumenal cells and possibly a distinct one for myoepithelial cells. Growth and differentiation are controlled by both hormones and local factors.
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- Banerjee M. R., Rogers F. M. Stimulation of the synthesis of macromolecules by ovarian hormones during early development of the mouse mammary gland. J Endocrinol. 1971 Jan;49(1):39–49. doi: 10.1677/joe.0.0490039. [DOI] [PubMed] [Google Scholar]
- Bennett D. C., Peachey L. A., Durbin H., Rudland P. S. A possible mammary stem cell line. Cell. 1978 Sep;15(1):283–298. doi: 10.1016/0092-8674(78)90104-6. [DOI] [PubMed] [Google Scholar]
- Freeman C. S., Topper Y. J. Progesterone and glucocorticoid in relation to the growth and differentiation of mammary epithelium. J Toxicol Environ Health. 1978 Mar-May;4(2-3):269–282. doi: 10.1080/15287397809529661. [DOI] [PubMed] [Google Scholar]
- Haslam S. Z., Bern H. A. Histopathogenesis of 7,12-diemthylbenz(a)anthracene-induced rat mammary tumors. Proc Natl Acad Sci U S A. 1977 Sep;74(9):4020–4024. doi: 10.1073/pnas.74.9.4020. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McManus M. J., Welsch C. W. Hormone-induced ductal DNA synthesis of human breast tissues maintained in the athymic nude mouse. Cancer Res. 1981 Sep;41(9 Pt 1):3300–3305. [PubMed] [Google Scholar]
- NANDI S. Endocrine control of mammarygland development and function in the C3H/ He Crgl mouse. J Natl Cancer Inst. 1958 Dec;21(6):1039–1063. [PubMed] [Google Scholar]
- Russo J., Russo I. H. DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J Natl Cancer Inst. 1978 Dec;61(6):1451–1459. [PubMed] [Google Scholar]
- Russo J., Russo I. H. Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res. 1980 Aug;40(8 Pt 1):2677–2687. [PubMed] [Google Scholar]
- Russo J., Wilgus G., Russo I. H. Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion. Am J Pathol. 1979 Sep;96(3):721–736. [PMC free article] [PubMed] [Google Scholar]