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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1982 Dec;79(23):7460–7464. doi: 10.1073/pnas.79.23.7460

Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2.

D Meruelo, M Offer, A Rossomando
PMCID: PMC347359  PMID: 6961423

Abstract

The region of chromosome 2 between H-13 and H-3 has been shown to contain loci coding for a variety of other alloantigens, including Ly-4 and the locus coding for beta 2-microglobulin. Herein we show that Ly-6 and Ly-11 are coded for by genes in a segment of chromosome 2 adjacent to the H-3-H-13 region and that this segment of chromosome also contains the tightly linked loci coding for antigens Ala-1, DAG, H9/25, H-30, Ly-8, and ThB. In addition, at least one locus (and probably more) affecting susceptibility to leukemia induction is found within this gene cluster.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colombatti A., Hughes E. N., Taylor B. A., August J. T. Gene for a major cell surface glycoprotein of mouse macrophages and other phagocytic cells is on chromosome 2. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1926–1929. doi: 10.1073/pnas.79.6.1926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Croce C. M., Linnenbach A., Huebner K., Parnes J. R., Margulies D. H., Appella E., Seidman J. G. Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5754–5758. doi: 10.1073/pnas.78.9.5754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eckhardt L. A., Herzenberg L. A. Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression. Immunogenetics. 1980;11(3):275–291. doi: 10.1007/BF01567794. [DOI] [PubMed] [Google Scholar]
  4. Goding J. W., Walker I. D. Allelic forms of beta 2-microglobulin in the mouse. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7395–7399. doi: 10.1073/pnas.77.12.7395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Haldane J B, Waddington C H. Inbreeding and Linkage. Genetics. 1931 Jul;16(4):357–374. doi: 10.1093/genetics/16.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Horton M. A., Hetherington C. M. Genetic linkage of Ly-6 and Thy-1 loci in the mouse. Immunogenetics. 1980;11(5):521–525. doi: 10.1007/BF01567820. [DOI] [PubMed] [Google Scholar]
  7. Itakura K., Hutton J. J., Boyse E. A., Old L. J. Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse. Transplantation. 1972 Mar;13(3):239–243. doi: 10.1097/00007890-197203000-00007. [DOI] [PubMed] [Google Scholar]
  8. McKenzie I. F., Potter T. Murine lymphocyte surface antigens. Adv Immunol. 1979;27:179–338. doi: 10.1016/s0065-2776(08)60263-1. [DOI] [PubMed] [Google Scholar]
  9. Meruelo D., Offer M., Flieger N. Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. J Exp Med. 1981 Oct 1;154(4):1201–1211. doi: 10.1084/jem.154.4.1201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Meruelo D., Paolino A., Flieger N., Offer M. Definition of a new T lymphocyte cell surface antigen, Ly 11.2. J Immunol. 1980 Dec;125(6):2713–2718. [PubMed] [Google Scholar]
  11. Meruelo D., Paolino A., Flieger N., Offer M., Dworkin J. Ly 11.2: a cell surface antigen that may identify murine lymphocytes susceptible to transformation by oncogenic agents. Fed Proc. 1981 Oct;40(12):2717–2720. [PubMed] [Google Scholar]
  12. Michaelson J. Genetic polymorphism of beta 2-microglobulin (B2m) maps to the H-3 region of chromosome 2. Immunogenetics. 1981;13(1-2):167–171. doi: 10.1007/BF00524613. [DOI] [PubMed] [Google Scholar]
  13. Miller O. J., Miller D. A., Kouri R. E., Allderdice P. W., Dev V. G., Grewal M. S., Hutton J. J. Identification of the mouse karyotype by quinacrine fluorescence, and tentative assignment of seven linkage groups. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1530–1533. doi: 10.1073/pnas.68.7.1530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Poulik M. D., Ferrone S., Pellegrino M. A., Sevier D. E., Oh S. K., Reisfeld R. A. Association of HL-A antigens and beta 2-microglobulin: concepts and questions. Transplant Rev. 1974;21(0):106–125. doi: 10.1111/j.1600-065x.1974.tb01548.x. [DOI] [PubMed] [Google Scholar]
  15. SNELL G. D., BUNKER H. P. HISTOCOMPATIBILITY GENES OF MICE. IV. THE POSITION O H-3 IN THE FIFTH LINKAGE GROUP. Transplantation. 1964 Nov;2:743–751. [PubMed] [Google Scholar]
  16. Sachs J. A., Huber B., Peña-Martinez J., Festenstein H. Genetic studies and effect on skin allograft survival of DBA-2 DAG, Ly, and M-locus antigens. Transplant Proc. 1973 Dec;5(4):1385–1387. [PubMed] [Google Scholar]
  17. Snell G. D., Cherry M., McKenzie I. F., Bailey D. W. Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108–1111. doi: 10.1073/pnas.70.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Snell G. D., Cherry M., McKenzie I. F., Bailey D. W. Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108–1111. doi: 10.1073/pnas.70.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Snell G. D., Cudkowicz G., Bunker H. P. Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group. Transplantation. 1967 May;5(3):492–503. doi: 10.1097/00007890-196705000-00011. [DOI] [PubMed] [Google Scholar]
  20. Swank R. T., Bailey D. W. Recombinant inbred lines: value in the genetic analysis of biochemical variants. Science. 1973 Sep 28;181(4106):1249–1252. doi: 10.1126/science.181.4106.1249. [DOI] [PubMed] [Google Scholar]
  21. Tada N., Kimura S., Hatzfeld A., Hämmerling U. Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Immunogenetics. 1980;11(5):441–449. doi: 10.1007/BF01567813. [DOI] [PubMed] [Google Scholar]
  22. Takei F., Galfrè G., Alderson T., Lennox E. S., Milstein C. H 9/25 monoclonal antibody recognizes a new allospecificity of mouse lymphocyte subpopulations: strain and tissue distribution. Eur J Immunol. 1980 Apr;10(4):241–246. doi: 10.1002/eji.1830100404. [DOI] [PubMed] [Google Scholar]

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