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. 1982 Dec;79(23):7479–7483. doi: 10.1073/pnas.79.23.7479

Identification of idiotypic receptors on reovirus-specific cytolytic T cells.

H C Ertl, M I Greene, J H Noseworthy, B N Fields, J T Nepom, D R Spriggs, R W Finberg
PMCID: PMC347363  PMID: 6984189

Abstract

Cytolytic T lymphocytes (Tc) specific for cells infected with reovirus type 3 were shown to lyse an uninfected B-cell hybridoma line (designated 87.92.6). This hybridoma expresses and secretes an anti-idiotypic antibody that reacts with a monoclonal antibody (termed G-5). G-5 recognizes a domain on the hemagglutinin of the reovirus that is relevant to virus tropism. The Tc cell response was H-2 restricted and could be inhibited by G-5. As shown by limiting dilution analysis, identical clones lysed reovirus-infected and anti-idiotype-bearing target cells. Tc cells induced by a variant of wild-type reovirus type 3 (immunologically selected by resistance to neutralization by G-5) were unable to recognize the anti-idiotype-bearing cells although they lysed reovirus type 3-infected tumor cells. We conclude that Tc cells must bear determinants that bind anti-idiotype molecules and, furthermore, that B cells and cytolytic T cells can share these idiotypic determinants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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