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. 1982 Dec;79(23):7518–7521. doi: 10.1073/pnas.79.23.7518

Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.

M Chow, D Baltimore
PMCID: PMC347371  PMID: 6296837

Abstract

Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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