Abstract
The purpose of this retrospective study was to investigate the incidence of bone metastases as the first sign of metastatic spread in patients with primary solid malignant tumours. Between January 1987 and December 1998, we treated 867 patients suffering from primary solid malignant tumours. Their average age was 67 (range: 30–96) years and all were thoroughly investigated with a complete physical examination and laboratory tests as well as imaging studies and bone scans. No bone metastases were found at the time of the initial diagnosis, and the patients were then re-assessed every 6 months for the first 5 years and then once a year. We found that, regardless of treatment, bone metastases appeared in a certain number of patients and that after excluding patients with prostate cancer a bone metastasis was the first sign of “recurrence” in 1.3% of the patients with a known primary solid malignant tumour.
Résumé
Le but de cette é tude r é trospective é tait de rapporter la fr é quence des m é tastases osseuses comme premier signe m é tastatique, chez des patients ayant une tumeur solide primitive connue. De janvier 1987 à décembre 1998 nous avons traité 867 malades souffrant de tumeurs solides primitives. Leur âge moyen était de 67 (30–96) ans. Tous les malades ont eu un examen complet y compris les études d’imagerie et la scintigraphie osseuse. Aucune métastase osseuse n’a été trouvé au diagnostic initial. Les malades ont été évalués tous les 6 mois pendant les 5 premières années et ensuite une fois par an. Sans tenir compte du traitement, nous avons constaté que les métastases osseuses apparaissaient chez un certain nombre de malades. En excluant les malades avec un cancer prostatique, les métastases osseuses étaient le premier signe de récidive chez 1,3% des malades avec une tumeur solide primitive connue.
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Footnotes
First presented at the SICOT Congress in San Diego, CA, USA, 2002.
References
- 1.Bortolus Radiol. 1983;Med:406. [Google Scholar]
- 2.Brown HK, Healy JH (2001) Metastatic cancer to the bone. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer principles & practice of oncology, 6th edn. Lippincot, Philadelphia, p 2716
- 3.Dorfman HD, Czerniak B (1998) Metastatic tumors in bone. In: Dorfman HD, Czerniak B (eds) Bone tumors. Mosby, St. Louis, pp 1009–1040
- 4.Garnesale PG (1998) Malignant tumors of bone. In: Canale TS (ed) Campbell’s operative orthopaedics, 9th edn. Mosby, St. Louis, p 732
- 5.Gilbert Ann Neurol. 1978;3:40. doi: 10.1002/ana.410030107. [DOI] [PubMed] [Google Scholar]
- 6.Joo Oncology. 1979;36:94. doi: 10.1159/000225325. [DOI] [PubMed] [Google Scholar]
- 7.Karnofsky DA, Burchenal JH (1949) Clinical evaluation of chemotherapeutic agents in cancer. In: McLeod CM (ed) Evaluation of chemotherapeutic agents. Columbia University, New York, p 191
- 8.Malawer MM, Henshaw RM, Shmookler BM (1997) Principles of orthopaedic oncology. In: Dee R (ed) Principles of orthopaedic practice, 2nd edn. McGraw-Hill, New York, pp 225–271
- 9.Mercandante Pain. 1997;69:1. doi: 10.1016/S0304-3959(96)03267-8. [DOI] [PubMed] [Google Scholar]
- 10.NielsenJ Clin Oncol 199195091705581 [Google Scholar]
- 11.Sugarbaker P (1996) Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology. In: Sugarbaker PH (ed) Peritoneal carcinomatosis. Principles of management. Kluwer, Boston, pp 79–100 [DOI] [PubMed]
- 12.Wilson J Nucl Med. 1981;22:594. [PubMed] [Google Scholar]
- 13.Young JM, Funk FJ Jr (1953) Incidence of tumor metastasis to the lumbar spine: a comparative study of roentgenographic changes and gross lesions. J Bone Joint Surg [Am] 35:55–64 [PubMed]