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. 1982 Jul;37(1):250–254. doi: 10.1128/iai.37.1.250-254.1982

Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin.

J C Sadoff, G A Buck, B H Iglewski, M J Bjorn, N B Groman
PMCID: PMC347520  PMID: 6179878

Abstract

The immunodominant determinant of Pseudomonas toxin A was shown to cross-react with a normally inaccessible determinant in fragment A of diphtheria toxin. Trypsin-treated diphtheria toxin and fragment A of diphtheria toxin inhibited binding of toxin A antibody to whole toxin A, whereas whole diphtheria toxin did not inhibit this reaction. However, even at the lowest stringency no hybridization was detected between diphtheria tox probe and Pseudomonas aeruginosa DNA.

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Selected References

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