Abstract
Cotton rats infected intranasally with respiratory syncytial virus and immunosuppressed with cyclophosphamide shed virus for at least 7 weeks. Dissemination of virus beyond the respiratory tract was observed. In contrast, virus was recovered from infected, non-immunosuppressed rats for only 1 week, and only from the respiratory tract.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blandford G. Studies on the immune response and pathogenesis of Sendai virus infection of mice. III. The effects of cyclophosphamide. Immunology. 1975 May;28(5):871–883. [PMC free article] [PubMed] [Google Scholar]
- Gardner P. S., McQuillin J., Court S. D. Speculation on pathogenesis in death from respiratory syncytial virus infection. Br Med J. 1970 Feb 7;1(5692):327–330. doi: 10.1136/bmj.1.5692.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobs J. W., Peacock D. B., Corner B. D., Caul E. O., Clarke S. K. Respiratory syncytial and other viruses associated with respiratory disease in infants. Lancet. 1971 May 1;1(7705):871–876. doi: 10.1016/S0140-6736(71)92440-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kapikian A. Z., Mitchell R. H., Chanock R. M., Shvedoff R. A., Stewart C. E. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol. 1969 Apr;89(4):405–421. doi: 10.1093/oxfordjournals.aje.a120954. [DOI] [PubMed] [Google Scholar]
- Kim H. W., Canchola J. G., Brandt C. D., Pyles G., Chanock R. M., Jensen K., Parrott R. H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969 Apr;89(4):422–434. doi: 10.1093/oxfordjournals.aje.a120955. [DOI] [PubMed] [Google Scholar]
- Prince G. A., Jenson A. B., Horswood R. L., Camargo E., Chanock R. M. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol. 1978 Dec;93(3):771–791. [PMC free article] [PubMed] [Google Scholar]
- SHEDDEN W. I., EMERY J. L. IMMUNOFLUORESCENT EVIDENCE OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN CASES OF GIANT CELL BRONCHIOLITIS IN CHILDREN. J Pathol Bacteriol. 1965 Jan;89:343–347. [PubMed] [Google Scholar]
- Suffin S. C., Kaufmann A. F., Whitaker B., Muck K. B., Prince G. A., Porter D. D. Legionella pneumophila: identification in tissue sections by a new immunoenzymatic procedure. Arch Pathol Lab Med. 1980 Jun;104(6):283–286. [PubMed] [Google Scholar]