Abstract
A sensitive radioimmunoassay was used to determine levels of herpes simplex virus (HSV)-specific immunoglobulin A (IgA) in serial serum samples drawn from patients with primary HSV infections and from persons with recurrent HSV infections, and in single samples from 90 healthy adults. Significantly rising HSV IgA titers were detected in patients with primary infections, whereas those with recurrent infections had nonfluctuating titers. Sera of IgG-seropositive healthy adults were all positive for HSV-specific IgA without special pretreatment.
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- BUDDINGH G. J., SCHRUM D. I., LANIER J. C., GUIDRY D. J. Studies of the natural history of herpes simplex infections. Pediatrics. 1953 Jun;11(6):595–610. [PubMed] [Google Scholar]
- Douglas R. G., Jr, Couch R. B. A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans. J Immunol. 1970 Feb;104(2):289–295. [PubMed] [Google Scholar]
- El Falaky I. H., Vestergaard B. F., Hornsleth A. IgG, IgA and IgM antibody responses in patients with acute genital and non-genital herpetic lesions determined by the indirect fluorescent antibody method. Scand J Infect Dis. 1977;9(2):79–84. doi: 10.3109/inf.1977.9.issue-2.05. [DOI] [PubMed] [Google Scholar]
- Friedman M. G. A population screening test for antibody to measles virus. Isr J Med Sci. 1981 Nov;17(11):1045–1050. [PubMed] [Google Scholar]
- Friedman M. G., Leventon-Kriss S., Sarov I. Sensitive solid-phase radioimmunoassay for detection of human immunoglobulin G antibodies to varicella-zoster virus. J Clin Microbiol. 1979 Jan;9(1):1–10. doi: 10.1128/jcm.9.1.1-10.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hacham M., Leventon-Kriss S., Sarov I. Enzyme-linked immunosorbent assay for detection of virus-specific IgM antibodies to varicella-zoster virus. Intervirology. 1980;13(4):214–222. doi: 10.1159/000149128. [DOI] [PubMed] [Google Scholar]
- Haikin H., Leventon-Kriss S., Sarov I. Antibody to varicella-zoster virus-induced membrane antigen: immunoperoxidase assay with air-dried target cells. J Infect Dis. 1979 Oct;140(4):601–604. doi: 10.1093/infdis/140.4.601. [DOI] [PubMed] [Google Scholar]
- Haikin H., Sarov I. Immunoperoxidase antibody to human cytomegalovirus-induced membrane antigen assay in the absence of interfering immunoglobulin G receptors. Intervirology. 1980;14(3-4):155–159. doi: 10.1159/000149177. [DOI] [PubMed] [Google Scholar]
- Halonen P., Bennich H., Torfason E., Karlsson T., Ziola B., Matikainen M. T., Hjertsson E., Wesslen T. Solid-phase radioimmunoassay of serum immunoglobulin A antibodies to respiratory syncytial virus and adenovirus. J Clin Microbiol. 1979 Aug;10(2):192–197. doi: 10.1128/jcm.10.2.192-197.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hornsleth A., Leerhoy J., Grauballe P., Spanggaard H. Persistence of rubellavirus-specific immunoglobulin M and immunoglobulin A antibodies: investigation of successive serum samples with lowered immunoglobulin G concentration. Infect Immun. 1975 Apr;11(4):804–808. doi: 10.1128/iai.11.4.804-808.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaufman H. E., Brown D. C., Ellison E. M. Recurrent herpes in the rabbit and man. Science. 1967 Jun 23;156(3782):1628–1629. doi: 10.1126/science.156.3782.1628. [DOI] [PubMed] [Google Scholar]
- Kimmel N., Friedman M. G., Sarov I. Detection of human cytomegalovirus-specific IgG antibodies by a sensitive solid-phase radioimmunoassay and by a rapid-screening test. J Med Virol. 1980;5(3):195–203. doi: 10.1002/jmv.1890050304. [DOI] [PubMed] [Google Scholar]
- McCarthy D., Goddard D. H., Pell B. K., Holborow E. J. Intrinsically stable IgG aggregates. J Immunol Methods. 1981;41(1):63–74. doi: 10.1016/0022-1759(81)90274-x. [DOI] [PubMed] [Google Scholar]
- Nahmias A. J., Roizman B. Infection with herpes-simplex viruses 1 and 2. 1. N Engl J Med. 1973 Sep 27;289(13):667–674. doi: 10.1056/NEJM197309272891305. [DOI] [PubMed] [Google Scholar]
- Nikoskelainen J., Neel E. U., Stevens D. A. Epstein-Barr virus-specific serum immunoglobulin A as an acute-phase antibody in infectious mononucleosis. J Clin Microbiol. 1979 Jul;10(1):75–79. doi: 10.1128/jcm.10.1.75-79.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ratner J. J., Sanford B. A., Smith K. O. Use of protein A-treated sera in unmasking herpes simplex virus type 1 (HSV-1) immunoglobulin A and identifying HSV-1 immunoglobulin G as the predominant neutralizing antibody. J Clin Microbiol. 1979 Oct;10(4):415–418. doi: 10.1128/jcm.10.4.415-418.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tokumaru T. A possible role of gamma-A-immunoglobulin in herpes simplex virus infection in man. J Immunol. 1966 Aug;97(2):248–259. [PubMed] [Google Scholar]
- Zweerink H. J., Stanton L. W. Immune response to herpes simplex virus infections: virus-specific antibodies in sera from patients with recurrent facial infections. Infect Immun. 1981 Feb;31(2):624–630. doi: 10.1128/iai.31.2.624-630.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]