Correction to “Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core”

A mistake has been found in the article on page 18444. The second paragraph should read:

“Here we explored whether limit size particles compatible with such structures could be generated using PEG-lipid as the surface lipid. In this regard a vesicle containing an internal aqueous core of 5 nm diameter has an outside-to-inside surface area ratio of 6.8 (assuming a bilayer thickness of 4 nm), indicating that the outer monolayer requires the presence of lipids that provide an interfacial area approximately 7 times larger than the inner monolayer area. Assuming that the interfacial area for a lipid such as DLinKC2-DMA is similar to dioleoylphosphatidylcholine (0.7 nm²),²³ it is straightforward to show that approximately 10 mol % PEG₂₀₀₀-lipid (surface area per molecule 36 nm²)²⁴ would be required to coat inverted micelles composed of DLinKC2DMA with an aqueous core 5 nm in diameter.”

The corrections neither affect the calculation that follows nor the results presented in this article.