Abstract
The resistance of Pseudomonas aeruginosa to phagocytosis by polymorphonuclear leukocytes was overcome by opsonization with antibody to slime glycolipoprotein or, to a lesser extent, with complement. Resistance was most effectively overcome in the presence of both. Protection against viable-cell challenge conferred by anti-glycolipoprotein serum in experimental infection is discussed briefly in the light of these findings.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartell P. F., Krikszens A. Influence of anti-slime glycolipoprotein serum on the interaction between Pseudomonas aeruginosa and macrophages. Infect Immun. 1980 Mar;27(3):777–783. doi: 10.1128/iai.27.3.777-783.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bartell P. F., Orr T. E., Chudio B. Purification and Chemical Composition of the Protective Slime Antigen of Pseudomonas aeruginosa. Infect Immun. 1970 Nov;2(5):543–548. doi: 10.1128/iai.2.5.543-548.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bartell P. F., Orr T. E., Garcia M. The lethal events in experimental Pseudomonas aeruginosa infection of mice. J Infect Dis. 1968 Apr;118(2):165–172. doi: 10.1093/infdis/118.2.165. [DOI] [PubMed] [Google Scholar]
- Bartell P. F., Orr T. E., Lam G. K. Polysaccharide depolymerase associated with bacteriophage infection. J Bacteriol. 1966 Jul;92(1):56–62. doi: 10.1128/jb.92.1.56-62.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bjornson A. B., Michael J. G. Contribution of humoral and cellular factors to the resistance to experimental infection by Pseudomonas aeruginosa in mice. I. Interaction between immunoglobulins, heat-labile serum factors, and phagocytic cells in the killing of bacteria. Infect Immun. 1971 Oct;4(4):462–467. doi: 10.1128/iai.4.4.462-467.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Castillo F. J., Bartell P. F. Studies on the bacteriophage 2 receptors of Pseudomonas aeruginosa. J Virol. 1974 Oct;14(4):904–909. doi: 10.1128/jvi.14.4.904-909.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dimitracopoulos G., Bartell P. F. Slime glycolipoproteins and the pathogenicity of various strains of Pseudomonas aeruginosa in experimental infection. Infect Immun. 1980 Nov;30(2):402–408. doi: 10.1128/iai.30.2.402-408.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dimitracopoulos G., Sensakovic J. W., Bartell P. F. Slime of Pseudomonas aeruginosa: in vivo production. Infect Immun. 1974 Jul;10(1):152–156. doi: 10.1128/iai.10.1.152-156.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lynn M., Sensakovic J. W., Bartell P. F. In vivo distribution of Pseudomonas aeruginosa slime glycolipoprotein: association with leukocytes. Infect Immun. 1977 Jan;15(1):109–114. doi: 10.1128/iai.15.1.109-114.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peterson P. K., Kim Y., Schmeling D., Lindemann M., Verhoef J., Quie P. G. Complement-mediated phagocytosis of Pseudomonas aeruginosa. J Lab Clin Med. 1978 Dec;92(6):883–894. [PubMed] [Google Scholar]
- Pier G. B., Sidberry H. F., Zolyomi S., Sadoff J. C. Isolation and characterization of a high-molecular-weight polysaccharide from the slime of Pseudomonas aeruginosa. Infect Immun. 1978 Dec;22(3):908–918. doi: 10.1128/iai.22.3.908-918.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sensakovic J. W., Bartell P. F. Glycolipoprotein from Pseudomonas aeruginosa as a protective antigen against P. aeruginosa infection in mice. Infect Immun. 1977 Nov;18(2):304–309. doi: 10.1128/iai.18.2.304-309.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sensakovic J. W., Bartell P. F. The slime of Pseudomonas aeruginosa: biological characterization and possible role in experimental infection. J Infect Dis. 1974 Feb;129(2):101–109. doi: 10.1093/infdis/129.2.101. [DOI] [PubMed] [Google Scholar]