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. 1982 Jul;37(1):387–389. doi: 10.1128/iai.37.1.387-389.1982

Intestinal immunoglobulin A responses in rabbits to a Salmonella typhi strain harboring a Shigella sonnei plasmid.

D F Keren, H H Collins, L S Baron, D J Kopecko, S B Formal
PMCID: PMC347539  PMID: 7049953

Abstract

Salmonella typhi 5076-IC, which contains a plasmid that encodes the form I antigen of Shigella sonnei and which expresses S. typhi 9 and 12 and S. sonnei form I antigens, was used to immunize rabbits via chronically isolated ileal loops. Intestinal immunoglobulin A activity was detected against S. typhi, S. sonnei form I, and S. typhi strain 5076-IC. Thus S. typhi 5076-IC can effectively elicit mucosal immunoglobulin A to both S. typhi and S. sonnei.

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Selected References

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  1. DuPont H. L., Hornick R. B., Snyder M. J., Libonati J. P., Formal S. B., Gangarosa E. J. Immunity in shigellosis. II. Protection induced by oral live vaccine or primary infection. J Infect Dis. 1972 Jan;125(1):12–16. doi: 10.1093/infdis/125.1.12. [DOI] [PubMed] [Google Scholar]
  2. Formal S. B., Baron L. S., Kopecko D. J., Washington O., Powell C., Life C. A. Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain. Infect Immun. 1981 Dec;34(3):746–750. doi: 10.1128/iai.34.3.746-750.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Formal S. B., Kent T. H., Austin S., Labrec E. H. Fluorescent-antibody and histological study of vaccinated and control monkeys challenged with Shigella flexneri. J Bacteriol. 1966 Jun;91(6):2368–2376. doi: 10.1128/jb.91.6.2368-2376.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Formal S. B., Kent T. H., May H. C., Palmer A., Falkow S., LaBrec E. H. Protection of monkeys against experimental shigellosis with a living attenuated oral polyvalent dysentery vaccine. J Bacteriol. 1966 Jul;92(1):17–22. doi: 10.1128/jb.92.1.17-22.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Formal S. B., Labrec E. H., Palmer A., Falkow S. Protection of Monkeys Against Experimental Shigellosis with Attenuated Vaccines. J Bacteriol. 1965 Jul;90(1):63–68. doi: 10.1128/jb.90.1.63-68.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gilman R. H., Hornick R. B., Woodard W. E., DuPont H. L., Snyder M. J., Levine M. M., Libonati J. P. Evaluation of a UDP-glucose-4-epimeraseless mutant of Salmonella typhi as a liver oral vaccine. J Infect Dis. 1977 Dec;136(6):717–723. doi: 10.1093/infdis/136.6.717. [DOI] [PubMed] [Google Scholar]
  7. Grahneis H. Successful field trials with oral killed Shigella sonnei vaccine. Acta Microbiol Acad Sci Hung. 1974;21(1-2):75–80. [PubMed] [Google Scholar]
  8. Keren D. F., Collins H. H., Gemski P., Holt P. S., Formal S. B. Role of antigen form in development of mucosal immunoglobin A response to Shigella flexneri Antigens. Infect Immun. 1981 Mar;31(3):1193–1202. doi: 10.1128/iai.31.3.1193-1202.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Keren D. F., Elliott H. L., Brown G. D., Yardley J. H. Atrophy of villi with hypertrophy and hyperplasia of Paneth cells in isolated (thiry-Vella) ileal loops in rabbits. Light-microscopic studies. Gastroenterology. 1975 Jan;68(1):83–93. [PubMed] [Google Scholar]
  10. Keren D. F. Enzyme-linked immunosorbent assay for immunoglobulin G and immunoglobulin A antibodies to Shigella flexneri antigens. Infect Immun. 1979 May;24(2):441–448. doi: 10.1128/iai.24.2.441-448.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Keren D. F., Holt P. S., Collins H. H., Gemski P., Formal S. B. The role of Peyer's patches in the local immune response of rabbit ileum to live bacteria. J Immunol. 1978 Jun;120(6):1892–1896. [PubMed] [Google Scholar]
  12. Keren D. F., Holt P. S., Collins H. H., Gemski P., Formal S. B. Variables affecting local immune response in ileal loops: role of immunization schedule, bacterial flora, and postsurgical inflammation. Infect Immun. 1980 Jun;28(3):950–956. doi: 10.1128/iai.28.3.950-956.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Keren D. F., Kern S. E., Bauer D. H., Scott P. J., Porter P. Direct demonstration in intestinal secretions of an IgA memory response to orally administered Shigella flexneri antigens. J Immunol. 1982 Jan;128(1):475–479. [PubMed] [Google Scholar]
  14. Keren D. F., Scott P. J., Bauer D. Variables affecting the local immune response in Thiry-Vella loops. II. Stability of antigen-specific IgG and secretory IgA in acute and chronic Thiry-Vella loops. J Immunol. 1980 Jun;124(6):2620–2624. [PubMed] [Google Scholar]
  15. Kétyi I., Rauss K., Vertényi A. Oral immunization against dysentery. Acta Microbiol Acad Sci Hung. 1974;21(1-2):81–85. [PubMed] [Google Scholar]
  16. Mel D. M., Terzin A. L., Vuksić L. Studies on vaccination against bacillary dysentery. 1. Immunization of mice against experimental Shigella infection. Bull World Health Organ. 1965;32(5):633–636. [PMC free article] [PubMed] [Google Scholar]
  17. Mel D. M., Terzin A. L., Vuksić L. Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial. Bull World Health Organ. 1965;32(5):647–655. [PMC free article] [PubMed] [Google Scholar]
  18. Mel D., Gangarosa E. J., Radovanovic M. L., Arsic B. L., Litvinjenko S. Studies on vaccination against bacillary dysentery. 6. Protection of children by oral immunization with streptomycin-dependent Shigella strains. Bull World Health Organ. 1971;45(4):457–464. [PMC free article] [PubMed] [Google Scholar]
  19. Wahdan M. H., Serie C., Germanier R., Lackany A., Cerisier Y., Guerin N., Sallam S., Geoffroy P., el Tantawi A. S., Guesry P. A controlled field trial of liver oral typhoid vaccine Ty21a. Bull World Health Organ. 1980;58(3):469–474. [PMC free article] [PubMed] [Google Scholar]

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