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Infection and Immunity logoLink to Infection and Immunity
. 1982 Jul;37(1):397–400. doi: 10.1128/iai.37.1.397-400.1982

Administration of a highly attenuated, live respiratory syncytial virus vaccine to adults and children.

P F Wright, R B Belshe, H W Kim, L P Van Voris, R M Chanock
PMCID: PMC347542  PMID: 7107009

Abstract

A highly attenuated respiratory syncytial virus (RSV) experimental vaccine, RSV ts-2, was sequentially evaluated in adults, seropositive children, and finally, fully susceptible seronegative children. The vaccine was administered intranasally in doses ranging from 10(5.2) to 10(6.3) PFU/ml. In both adults and children, the vaccine proved to be poorly infectious. Although poor infectivity would not have been predicted from tissue culture studies of RSV ts-2 growth, the human experience closely parallels the experience in a series of animal models, including the chimpanzee. The poor infectivity of this RSV vaccine virus preparation suggests that the postulated defect in the RSV ts-2 fusion protein may be important in determining in vivo infectivity of RSV.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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