Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1982 Aug;37(2):499–505. doi: 10.1128/iai.37.2.499-505.1982

Humoral immune response to oral microorganisms in periodontitis.

S L Doty, D E Lopatin, S A Syed, F N Smith
PMCID: PMC347562  PMID: 6126434

Abstract

Serum antibody titers from patients with periodontitis were compared with those from periodontally healthy subjects. With the micro-enzyme-linked immunosorbent assay, immunoglobulin G (IgG), IgA, and IgM antibody titers to isolates of Streptococcus sanguis, Actinomyces viscosus, Bacteroides gingivalis, Bacteroides melaninogenicus subsp. intermedius, Bacteroides gingivalis, Bacteroides melaninogenicus subsp. intermedius, Bacteroides ochraceus, and Fusobacterium nucleation were determined. Antibody titers of the IgG and IgA classes to B. melaninogenicus, B. ochraceus, F. nucleatum, and S. sanguis were found to be significantly higher in the controls than in the patients. No correlations were found with serum IgM titers. These findings indicate that periodonitis may be associated with depressed antibacterial serum antibody titers of the IgG and IgA classes.

Full text

PDF
499

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brandtzaeg P. Local factors of resistance in the gingival area. J Periodontal Res. 1966;1:19–42. doi: 10.1111/j.1600-0765.1966.tb01844.x. [DOI] [PubMed] [Google Scholar]
  2. Engvall E., Perlmann P. Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J Immunol. 1972 Jul;109(1):129–135. [PubMed] [Google Scholar]
  3. Evans R. T., Spaeth S., Mergenhagen S. E. Bactericidal antibody in mammalian serum to obligatorily anaerobic Gram-negative bacteria. J Immunol. 1966 Jul;97(1):112–119. [PubMed] [Google Scholar]
  4. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  5. Frey J. R., De Weck A. L., Geleick H., Polak L. The induction of immunological tolerance during the primary response. Int Arch Allergy Appl Immunol. 1972;42(2):278–299. doi: 10.1159/000230612. [DOI] [PubMed] [Google Scholar]
  6. Genco R. J. Immunoglobulins and periodontal disease. J Periodontol. 1970 Apr;41(4):196–201. doi: 10.1902/jop.1970.41.4.196. [DOI] [PubMed] [Google Scholar]
  7. Genco R. J., Mashimo P. A., Krygier G., Ellison S. A. Antibody-mediated effects on the periodontium. J Periodontol. 1974 May;45(5):330–337. doi: 10.1902/jop.1974.45.5.330. [DOI] [PubMed] [Google Scholar]
  8. Gilmour M. N., Nisengard R. J. Interactions between serum titres to filamentous bacteria and their relationship to human periodontal disease. Arch Oral Biol. 1974 Nov;19(11):959–968. doi: 10.1016/0003-9969(74)90081-8. [DOI] [PubMed] [Google Scholar]
  9. Hockett R. N., Loesche W. J., Sodeman T. M. Bacteraemia in asymptomatic human subjects. Arch Oral Biol. 1977;22(2):91–98. doi: 10.1016/0003-9969(77)90084-x. [DOI] [PubMed] [Google Scholar]
  10. Holmberg K., Killander J. Quantitative determination of immunoglobuline (IgG, IgA and IgM) and identification of IgA-type in the gingival fluid. J Periodontal Res. 1971;6(1):1–8. doi: 10.1111/j.1600-0765.1971.tb00581.x. [DOI] [PubMed] [Google Scholar]
  11. Horton J. E., Leikin S., Oppenheim J. J. Human lymphoproliferative reaction to saliva and dental plaque-deposits: an in vitro correlation with periodontal disease. J Periodontol. 1972 Sep;43(9):522–527. doi: 10.1902/jop.1972.43.9.522. [DOI] [PubMed] [Google Scholar]
  12. Horton J. E., Oppenheim J. J., Mergenhagen S. E. A role for cell-mediated immunity in the pathogenesis of periodontal disease. J Periodontol. 1974 May;45(5):351–360. doi: 10.1902/jop.1974.45.5.351. [DOI] [PubMed] [Google Scholar]
  13. Ivanyi L., Lehner T. Lymphocyte transformation by sonicates of dental plaque in human periodontal disease. Arch Oral Biol. 1971 Sep;16(9):1117–1121. doi: 10.1016/0003-9969(71)90216-0. [DOI] [PubMed] [Google Scholar]
  14. Ivanyi L., Lehner T. Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease. Arch Oral Biol. 1970 Nov;15(11):1089–1096. doi: 10.1016/0003-9969(70)90121-4. [DOI] [PubMed] [Google Scholar]
  15. Ivanyi L., Wilton J. M., Lehner T. Cell-mediated immunity in periodontal disease; cytotoxicity, migration inhibition and lymphocyte transformation studies. Immunology. 1972 Jan;22(1):141–145. [PMC free article] [PubMed] [Google Scholar]
  16. Katz D. H., Hamaoka T., Benacerraf B. Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells. J Exp Med. 1972 Dec 1;136(6):1404–1429. doi: 10.1084/jem.136.6.1404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kristoffersen T., Hofstad T. Antibodies in humans to an isolated antigen from oral fusobacteria. J Periodontal Res. 1970;5(2):110–115. doi: 10.1111/j.1600-0765.1970.tb00701.x. [DOI] [PubMed] [Google Scholar]
  18. Lopatin D. E., Peebles F. L., Woods R. W., Syed S. A. In-vitro evaluation in man of immuno-stimulation by subfractions of Actinomyces viscosus. Arch Oral Biol. 1980;25(1):23–29. doi: 10.1016/0003-9969(80)90151-x. [DOI] [PubMed] [Google Scholar]
  19. MERGENHAGEN S. E., DEARAUJO W. C. ANTIBODY TO LEPTOTRICHIA BUCCALIS IN HUMAN SERA. Arch Oral Biol. 1965 Jan-Feb;10:29–33. doi: 10.1016/0003-9969(65)90054-3. [DOI] [PubMed] [Google Scholar]
  20. Mergenhagen S. E., Tempel T. R., Snyderman R. Immunologic reactions and periodontal inflammation. J Dent Res. 1970 Mar-Apr;49(2):256–261. doi: 10.1177/00220345700490020901. [DOI] [PubMed] [Google Scholar]
  21. Mouton C., Hammond P. G., Slots J., Genco R. J. Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease. Infect Immun. 1981 Jan;31(1):182–192. doi: 10.1128/iai.31.1.182-192.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nisengard R. J., Beutner E. H. Immunologic studies of periodontal disease. V. IgG type antibodies and skin test responses to actinomyces and mixed oral flora. J Periodontol. 1970 Mar;41(3):149–152. doi: 10.1902/jop.1970.41.3.149. [DOI] [PubMed] [Google Scholar]
  23. Nisengard R. J., Newman M. N., Myers D., Horikoshi A. Humoral immunologic responses in idiopathic juvenile periodontitis (periodontosis). J Periodontol. 1980 Jan;51(1):30–33. doi: 10.1902/jop.1980.51.1.30. [DOI] [PubMed] [Google Scholar]
  24. Nisengard R. J. The role of immunology in periodontal disease. J Periodontol. 1977 Sep;48(9):505–516. doi: 10.1902/jop.1977.48.9.505. [DOI] [PubMed] [Google Scholar]
  25. Nisengard R. Immediate hypersensitivity and periodontal disease. J Periodontol. 1974 May;45(5):344–347. doi: 10.1902/jop.1974.45.5.2.344. [DOI] [PubMed] [Google Scholar]
  26. Orstavik D., Brandtzaeg P. Serum antibodies to plaque bacteria in subjects with dental caries and gingivitis. Scand J Dent Res. 1977 Jan-Feb;85(2):106–113. doi: 10.1111/j.1600-0722.1977.tb00540.x. [DOI] [PubMed] [Google Scholar]
  27. Ramfjord S. P. The Periodontal Disease Index (PDI). J Periodontol. 1967 Nov-Dec;38(6 Suppl):602–610. doi: 10.1902/jop.1967.38.6.602. [DOI] [PubMed] [Google Scholar]
  28. SILNESS J., LOE H. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121–135. doi: 10.3109/00016356408993968. [DOI] [PubMed] [Google Scholar]
  29. Sewell H. F., Gell P. G., Basu M. K. Immune responsiveness and oral immunization. Int Arch Allergy Appl Immunol. 1979;58(4):414–425. doi: 10.1159/000232221. [DOI] [PubMed] [Google Scholar]
  30. Shillitoe E. J., Lehner T. Immunoglobulins and complement in crevicular fluid, serum and saliva in man. Arch Oral Biol. 1972 Feb;17(2):241–247. doi: 10.1016/0003-9969(72)90206-3. [DOI] [PubMed] [Google Scholar]
  31. Slots J. The predominant cultivable microflora of advanced periodontitis. Scand J Dent Res. 1977 Jan-Feb;85(2):114–121. doi: 10.1111/j.1600-0722.1977.tb00541.x. [DOI] [PubMed] [Google Scholar]
  32. Steinberg A. I., Gershoff S. N. Quantitative differences in spirochetal antibody observed in periodontal disease. J Periodontol. 1968 Sep;39(5):286–289. doi: 10.1902/jop.1968.39.5.286. [DOI] [PubMed] [Google Scholar]
  33. Taichman N. S. Some perspectives on the pathogenesis of periodontal disease. J Periodontol. 1974 May;45(5):361–363. doi: 10.1902/jop.1974.45.5.2.361. [DOI] [PubMed] [Google Scholar]
  34. Thomas H. C., Parrott M. V. The induction of tolerance to a soluble protein antigen by oral administration. Immunology. 1974 Oct;27(4):631–639. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES