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The Journal of Headache and Pain logoLink to The Journal of Headache and Pain
. 2007 Dec 10;8(6):342–344. doi: 10.1007/s10194-007-0426-3

Headache in a patient with Klinefelter’s syndrome and hyperostosis frontalis interna

Sindhu Ramchandren 1,, David S Liebeskind 2
PMCID: PMC3476161  PMID: 18071629

Abstract

Hyperostosis frontalis interna (HFI) has been reported in older women, but reports in men are rare. We present a novel case of migraine headache in a gentleman with Klinefelter’s syndrome and HFI, along with a discussion of possible pathophysiologic mechanisms underlying both the headache and the HFI.

Keywords: Hyperostosis frontalis interna, Klinefelter’s syndrome, Headache, Migraine, Oestrogen

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