Abstract
Familial trigeminal neuralgia has been reported in 1–2% of cases consistent with an autosomal dominant inheritance. We present a Swiss family with several members suffering from occipital and nervus intermedius neuralgia alone or in combination. We suggest that peripheral sensory anastomoses or central convergence of afferent pathways could explain neuralgia affecting two cranial nerves. The pedigree has two main characteristics: (1) affected individuals in two generations and (2) in the first generation the father is affected, in the second generation all women are affected, and none of the men. This is suggestive of an X-linked dominant or an autosomal dominant mode of inheritance.
Keywords: Familial, Genetic, Occipital neuralgia, Nervus intermedius neuralgia
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Conflict of interest
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References
- 1.Savica R, Lagana A, Siracusano R, Calabro RS, Ferlazzo E, Musolino R. Idiopathic familial trigeminal neuralgia: a case report. Neurol Sci. 2007;28:196–198. doi: 10.1007/s10072-007-0820-2. [DOI] [PubMed] [Google Scholar]
- 2.Smyth P, Greenough G, Stommel E. Familial trigeminal neuralgia: case reports and review of the literature. Headache. 2003;43:910–915. doi: 10.1046/j.1526-4610.2003.03172.x. [DOI] [PubMed] [Google Scholar]
- 3.Testa D, Milanese C, La Mantia L, Mastrangelo M, Crenna P, Negri S. Familial trigeminal neuralgia in Charcot–Marie-Tooth disease. J Neurol. 1981;225:283–287. doi: 10.1007/BF00313301. [DOI] [PubMed] [Google Scholar]
- 4.Coffey RJ, Fromm GH. Familial trigeminal neuralgia and Charcot–Marie-Tooth neuropathy report of two families and review. Surg Neurol. 1991;35:49–53. doi: 10.1016/0090-3019(91)90202-K. [DOI] [PubMed] [Google Scholar]
- 5.Duff JM, Spinner RJ, Lindor NM, Dodick DW, Atkinson JL. Familial trigeminal neuralgia and contralateral hemifacial spasm. Neurology. 1999;53:216–218. doi: 10.1212/wnl.53.1.216. [DOI] [PubMed] [Google Scholar]
- 6.Knuckey NW, Gubbay SS. Familial trigeminal and glossopharyngeal neuralgia. Clin Exp Neurol. 1979;16:315–319. [PubMed] [Google Scholar]
- 7.The International Classification of Headache Disorders (2004) 2nd edn. Cephalalgia 24(suppl 1):9–160 [DOI] [PubMed]
- 8.Afridi SK, Shields KG, Bhola R, Goadsby PJ. Greater occipital nerve injection in primary headache syndromes—prolonged effects from a single injection. Pain. 2006;122:126–129. doi: 10.1016/j.pain.2006.01.016. [DOI] [PubMed] [Google Scholar]
- 9.Pascual-Leone A, Pascual-Leone Pascual A. Occipital neuralgia: another benign cause of “thunderclap headache”. J Neurol Neurosurg Psychiatry. 1992;55:411. doi: 10.1136/jnnp.55.5.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Chouret EE. The greater occipital neuralgia headache. Headache. 1967;7:33–34. doi: 10.1111/j.1526-4610.1967.hed0701033.x. [DOI] [PubMed] [Google Scholar]
- 11.Sulfaro MA, Gobetti JP. Occipital neuralgia manifesting as orofacial pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80:751–755. doi: 10.1016/S1079-2104(05)80261-6. [DOI] [PubMed] [Google Scholar]
- 12.Kinney MA, Wilson JL, Carmichael SW, Ruyter ML, Fulgham JR. Prolonged facial hypesthesia resulting from greater occipital nerve block. Clin Anat. 2003;16:362–365. doi: 10.1002/ca.10103. [DOI] [PubMed] [Google Scholar]
- 13.Bruyn GW. Nervus intermedius neuralgia (Hunt) Cephalalgia. 1984;4:71–78. doi: 10.1046/j.1468-2982.1984.0401071.x. [DOI] [PubMed] [Google Scholar]
- 14.Vanopdenbosch LJ, Verhoeven K, Casselman JW. Bell’s palsy with ipsilateral numbness. J Neurol Neurosurg Psychiatry. 2005;76:1017–1018. doi: 10.1136/jnnp.2004.043059. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.da Silva HM, Boullosa JL, Arruda MA. Secondary intermedius neuralgia-like pain in a young child. Cephalalgia. 2006;26:1483–1484. doi: 10.1111/j.1468-2982.2006.01215.x. [DOI] [PubMed] [Google Scholar]
- 16.Sessle BJ, Hu JW, Amano N, Zhong G. Convergence of cutaneous, tooth pulp, visceral, neck and muscle afferents onto nociceptive and non-nociceptive neurones in trigeminal subnucleus caudalis (medullary dorsal horn) and its implications for referred pain. Pain. 1986;27:219–235. doi: 10.1016/0304-3959(86)90213-7. [DOI] [PubMed] [Google Scholar]
- 17.Gantenbein AR, Goadsby PJ. Familial SUNCT. Cephalalgia. 2005;25:457–459. doi: 10.1111/j.1468-2982.2005.00874.x. [DOI] [PubMed] [Google Scholar]
- 18.Kihara T, Shimohama S. Occipital neuralgia evoked by facial herpes zoster infection. Headache. 2006;46:1590–1591. doi: 10.1111/j.1526-4610.2006.00616_2.x. [DOI] [PubMed] [Google Scholar]
- 19.Sampathkumar P, Drage LA, Martin DP. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc. 2009;84:274–280. doi: 10.4065/84.3.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Sato M, Ohashi J, Tsuchiya N, et al. Association of HLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFA promoter and NKp30 polymorphism, with postherpetic neuralgia (PHN) in the Japanese population. Genes Immun. 2002;3:477–481. doi: 10.1038/sj.gene.6363890. [DOI] [PubMed] [Google Scholar]
- 21.Casez O, Dananchet Y, Besson G. Migraine and somnambulism. Neurology. 2005;65:1334–1335. doi: 10.1212/01.wnl.0000180937.20774.20. [DOI] [PubMed] [Google Scholar]
- 22.Hublin C, Kaprio J, Partinen M, Heikkila K, Koskenvuo M. Prevalence and genetics of sleepwalking: a population-based twin study. Neurology. 1997;48:177–181. doi: 10.1212/wnl.48.1.177. [DOI] [PubMed] [Google Scholar]
- 23.Vries B, Frants RR, Ferrari MD, Maagdenberg AM. Molecular genetics of migraine. Hum Genet. 2009;126:115–132. doi: 10.1007/s00439-009-0684-z. [DOI] [PubMed] [Google Scholar]