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. 1982 Sep;37(3):1227–1233. doi: 10.1128/iai.37.3.1227-1233.1982

Plasmodium berghei malaria: blockage by immune complexes of macrophage receptors for opsonized plasmodia.

K M Brown, J P Kreier
PMCID: PMC347669  PMID: 6752023

Abstract

Immune complexes produced in vitro by mixing immune serum and soluble Plasmodium berghei antigens and immune complexes precipitated from serum of acutely infected rats blocked macrophage receptor sites for opsonized plasmodia. The immune complexes were precipitated from acute-phase serum, using polyethylene glycol, and their composition was determined by using a Raji cell immunofluorescence assay. The immune complexes contained immunoglobulin G (IgG), IgM, and malarial antigens. These results indicate that immune complexes in the serum of acutely infected animals may protect the plasmodia from the activities of macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boonpucknavig S., Wongsawang S., Boonpucknavig V., Bhamarapravati N. Serum-soluble malarial antigens and immune complex nephritis in Plasmodium berghei berghei infected mice. J Trop Med Hyg. 1976 Jun;79(6):116–119. [PubMed] [Google Scholar]
  2. Brooks C., Kreier J. P. Role of the surface coat in in vitro attachment and phagocytosis of Plasmodium berghei by peritoneal macrophages. Infect Immun. 1978 Jun;20(3):827–835. doi: 10.1128/iai.20.3.827-835.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chow J. S., Kreier J. P. Plasmodium berghei: adherence and phagocytosis by rat macrophages in vitro. Exp Parasitol. 1972 Feb;31(1):13–18. doi: 10.1016/0014-4894(72)90042-2. [DOI] [PubMed] [Google Scholar]
  4. Creighton W. D., Lambert P. H., Miescher P. A. Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol. J Immunol. 1973 Oct;111(4):1219–1227. [PubMed] [Google Scholar]
  5. Gravely S. M., Hamburger J., Kreier J. P. T and B cell population changes in young and in adult rats infected with Plasmodium berghei. Infect Immun. 1976 Jul;14(1):178–183. doi: 10.1128/iai.14.1.178-183.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Green T. J., Kreier J. P. Demonstration of the role of cytophilic antibody in resistance to malaria parasites (Plasmodium berghei) in rats. Infect Immun. 1978 Jan;19(1):138–145. doi: 10.1128/iai.19.1.138-145.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Green T. J., Morhardt M., Brackett R. G., Jacobs R. L. Serum inhibition of merozoite dispersal from Plasmodium falciparum schizonts: indicator of immune status. Infect Immun. 1981 Mar;31(3):1203–1208. doi: 10.1128/iai.31.3.1203-1208.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hamburger J., Kreier J. P. Plasmodium berghei: use of free blood stage parasites to demonstrate protective humoral activity in the serum of recovered rats. Exp Parasitol. 1976 Oct;40(2):158–169. doi: 10.1016/0014-4894(76)90078-3. [DOI] [PubMed] [Google Scholar]
  9. Houba V., Lambert P. H., Voller A., Soyanwo M. A. Clinical and experimental investigation of immune complexes in malaria. Clin Immunol Immunopathol. 1976 Jul;6(1):1–12. doi: 10.1016/0090-1229(76)90054-4. [DOI] [PubMed] [Google Scholar]
  10. June C. H., Contreras C. E., Perrin L. H., Lambert P. H., Miescher P. A. Circulating and tissue-bound immune complex formation in murine malaria. J Immunol. 1979 Jun;122(6):2154–2161. [PubMed] [Google Scholar]
  11. Miller L. H., Aikawa M., Dvorak J. A. Malaria (Plasmodium knowlesi) merozoites: immunity and the surface coat. J Immunol. 1975 Apr;114(4):1237–1242. [PubMed] [Google Scholar]
  12. Pestel J., Joseph M., Dessaint J. P., Capron A. Macrophage triggering by aggregated immunoglobulins. I. Delayed effect of IgG aggregates or immune complexes. J Immunol. 1981 May;126(5):1887–1891. [PubMed] [Google Scholar]
  13. Prior R. B., Kreier J. P. Plasmodium berghei freed from host erythrocytes by a continuous-flow ultrasonic system. Exp Parasitol. 1972 Oct;32(2):239–243. doi: 10.1016/0014-4894(72)90030-6. [DOI] [PubMed] [Google Scholar]
  14. Rao V. S., Grodzicki R. L., Mitchell M. S. Specific in vivo inhibition of macrophage receptors for cytophilic antibody by soluble immune complexes. Cancer Res. 1979 Jan;39(1):174–182. [PubMed] [Google Scholar]
  15. Seitz H. M. Demonstration of malarial antigens in the sera of Plasmodium berghei-infected mice. J Parasitol. 1972 Feb;58(1):179–180. [PubMed] [Google Scholar]
  16. Seitz H. M. The plasmodium berghei-infection in isogenic F1(C57B1 x DBA)-mice. II. Antibodies and antigens in the serum. Tropenmed Parasitol. 1976 Mar;27(1):33–43. [PubMed] [Google Scholar]
  17. Shear H. L., Nussenzweig R. S., Bianco C. Immune phagocytosis in murine malaria. J Exp Med. 1979 Jun 1;149(6):1288–1298. doi: 10.1084/jem.149.6.1288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Talkayangi T., Nakatake Y. Trypanosoma gambiense: Blocking ability of parasite and macrophage homogenates on attachment during phagocytosis. Exp Parasitol. 1975 Apr;37(2):218–222. doi: 10.1016/0014-4894(75)90073-9. [DOI] [PubMed] [Google Scholar]
  19. Theofilopoulos A. N., Dixon F. J., Bokisch V. A. Binding of soluble immune complexes to human lymphoblastoid cells. I. Characterization of receptors for IgG Fc and complement and description of the binding mechanism. J Exp Med. 1974 Oct 1;140(4):877–894. doi: 10.1084/jem.140.4.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Theofilopoulos A. N., Wilson C. B., Bokisch V. A., Dixon F. J. Binding of soluble immune complexes to human lymphoblastoid cells. II. Use of Raji cells to detect circulating immune complexes in animal and human sera. J Exp Med. 1974 Nov 1;140(5):1230–1244. doi: 10.1084/jem.140.5.1230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ward P. A., Kibukamusoke J. W. Evidence for soluble immune complexes in the pathogenesis of the glomerulonephritis of quartan malaria. Lancet. 1969 Feb 8;1(7589):283–285. doi: 10.1016/s0140-6736(69)91038-1. [DOI] [PubMed] [Google Scholar]
  22. ZUCKERMAN A. Auto-antibody in rats with Plasmodium berghei. Nature. 1960 Jan 16;185:189–190. doi: 10.1038/185189a0. [DOI] [PubMed] [Google Scholar]

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