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. 1982 Sep;37(3):1282–1284. doi: 10.1128/iai.37.3.1282-1284.1982

Trypanosoma brucei Infection Stimulates Receptor-Mediated Phagocytosis by Murine Peritoneal Macrophages

Joshua Fierer 1,†, Bridgitte A Askonas 1
PMCID: PMC347676  PMID: 6127316

Abstract

Trypanosoma brucei infection results in hypertrophy of the reticuloendothelial system. Peritoneal macrophages from infected mice were larger, spread out more on glass, and had increased receptor-mediated phagocytic activity both for C3b-and immunoglobulin G-coated erythrocytes. These observations suggest that macrophages were activated as a result of this infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clayton C. E., Selkirk M. E., Corsini C. A., Ogilvie B. M., Askonas B. A. Murine trypanosomiasis: cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells. Infect Immun. 1980 Jun;28(3):824–831. doi: 10.1128/iai.28.3.824-831.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clayton C. E. Trypanosoma brucei: influence of host strain and parasite antigenic type on infections in mice. Exp Parasitol. 1978 Apr;44(2):202–208. doi: 10.1016/0014-4894(78)90099-1. [DOI] [PubMed] [Google Scholar]
  3. Cohn Z. A. Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol. 1978 Sep;121(3):813–816. [PubMed] [Google Scholar]
  4. Corsini A. C., Clayton C., Askonas B. A., Ogilvie B. M. Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei. Clin Exp Immunol. 1977 Jul;29(1):122–131. [PMC free article] [PubMed] [Google Scholar]
  5. Finerty J. F., Krehl E. P., McKelvin R. L. Delayed-type hypersensitivity in mice immunized with Trypanosoma rhodesiense antigens. Infect Immun. 1978 May;20(2):464–467. doi: 10.1128/iai.20.2.464-467.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Griffin F. M., Jr, Bianco C., Silverstein S. C. Characterization of the macrophage receptro for complement and demonstration of its functional independence from the receptor for the Fc portion of immunoglobulin G. J Exp Med. 1975 Jun 1;141(6):1269–1277. doi: 10.1084/jem.141.6.1269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Griffin F. M., Jr Effects of soluble immune complexes on Fc receptor- and C3b receptor-mediated phagocytosis by macrophages. J Exp Med. 1980 Oct 1;152(4):905–919. doi: 10.1084/jem.152.4.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Griffin F. M., Jr, Griffin J. A. Augmentation of macrophage complement receptor function in vitro. II. Characterization of the effects of a unique lymphokine upon the phagocytic capabilities of macrophages. J Immunol. 1980 Aug;125(2):844–849. [PubMed] [Google Scholar]
  9. Griffin F. M., Jr, Silverstein S. C. Segmental response of the macrophage plasma membrane to a phagocytic stimulus. J Exp Med. 1974 Feb 1;139(2):323–336. doi: 10.1084/jem.139.2.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mayor-Withey K. S., Clayton C. E., Roelants G. E., Askonas B. A. Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow. Clin Exp Immunol. 1978 Dec;34(3):359–363. [PMC free article] [PubMed] [Google Scholar]
  11. Murray M., Murray P. K., Jennings F. W., Fisher E. W., Urquhart G. M. The pathology of Trypanosoma brucei infection in the rat. Res Vet Sci. 1974 Jan;16(1):77–84. [PubMed] [Google Scholar]
  12. Poltera A. A. Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain. Trans R Soc Trop Med Hyg. 1980;74(6):706–715. doi: 10.1016/0035-9203(80)90183-2. [DOI] [PubMed] [Google Scholar]
  13. Rittenberg M. B., Pratt K. L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969 Nov;132(2):575–581. doi: 10.3181/00379727-132-34264. [DOI] [PubMed] [Google Scholar]
  14. Schnyder J., Baggiolini M. Role of phagocytosis in the activation of macrophages. J Exp Med. 1978 Dec 1;148(6):1449–1457. doi: 10.1084/jem.148.6.1449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stevens D. R., Moulton J. E. Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages. Infect Immun. 1978 Mar;19(3):972–982. doi: 10.1128/iai.19.3.972-982.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vincendeau P., Caristan A., Pautrizel R. Macrophage function during Trypanosoma musculi infection in mice. Infect Immun. 1981 Nov;34(2):378–381. doi: 10.1128/iai.34.2.378-381.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]

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