Table 2.
Description of novela alleles of KIR framework loci
| Locus | Novel Allele | Most Similar Allele |
Codons (Amino Acid) Altered | GenBank Accession No. |
Cell ID |
|---|---|---|---|---|---|
| 2DL4 | 2DL4*01202 | 2DL4*01201 | 317 GCG (A)=>GCA (A) | GU830915 | GM17179 |
| 2DL4*013 | 2DL4*00801 | 115 GCA (A) =>ACA (T), 186 CCG (P)=>GCG (A) | GU830911 | GM17199 | |
| 2DL4*017 | 2DL4*00802 | 22 GGA (G)=>AGA (R) | GU830913 | GM17132 | |
| 2DL4*018 | 2DL4*00103 | 32 CGT (R)=>GGT (G), 174 GGC (G)=>AGC (S) | GU830914 | GM17137 | |
| 2DL4*019 | 2DL4*018 | 231 TTC (F) => TTT (F), 248 AAT (N) => AT (deletion, converts 10A to 9A) | GU830916 | GM17180 | |
| 2DL4*020 | 2DL4*00802 | 137 GAA (E) =>GTA (V) | GU830917 | GM17192 | |
| 2DL4*021 | 2DL4*00103 | 158 GAC (D)=>AAC (N) | GU830918 | GM17197 | |
| 2DL4*022 | 2DL4*00103 | 317 GCG (A)=>GTG (V) | GU830912 | GM17112 | |
| 3DL2 | 3DL2*00502 | 3DL2*00501 | 122 CAA (Q)=>CAG (Q) | GU944872 | GM17134 |
| 3DL2*01302 | 3DL2*01301 | 125 TCA (S)=>TCG (S) | GU944864 | GM17109 | |
| 3DL2*01303 | 3DL2*01301 | −18 ACT (T) =>ACG (T) | GU944868 | GM17122 | |
| 3DL2*025b | 3DL2*01301 | 145 CGC (R) =>CAC (H) | GU944875 | GM17165 | |
| 3DL2*028b | 3DL2*00103 | 49 ATC (I) =>TTC (F) | GU944876 | GM17166 | |
| 3DL2*029b | 3DL2*00201 | 75 CGG (R) =>CCG (P) | GU944870 | GM17126 | |
| 3DL2*032b | 3DL2*00103 | 226 TGG (W)=>CGG (R), 231 ATC (I) =>ATG (M) | GU065733 | GM17113 | |
| 3DL2*033b | 3DL2*00103 | 219 GTG (V)=>ATG (M) | GU944866 | GM17112 | |
| 3DL2*040b | 3DL2*01301 | 87 GCA (A) =>ACA (T) | GU944863 | GM17106 | |
| 3DL2*041b | 3DL2*032 | 433 GTT (V) =>TTT (F) | GU944871 | GM17128 | |
| 3DL2*057 | 3DL2*010 | 145 CGC (R) =>CAC (H) | GU944869 | GM17124 | |
| 3DL2*058 | 3DL2*00701 | 47 GTT (V) =>ATT (I) | GU944873 | GM17137 | |
| 3DL2*059 | 3DL2*00103 | 75 CGG (R)=>CCG (P), 145 CGC (R)=>CAC (H) | GU944874 | GM17142 | |
| 3DL2*060 | 3DL2*00302 | 62 GGT (G)=>AGT (S) | GU944877 | GM17172 | |
| 3DL2*061 | 3DL2*032 | 195 GTG (V)=>ATG (M) | GU944878 | GM17193 | |
| 3DL2*062 | 3DL2*00902 | 92 CTG (L)=>GTG (V) | GU944862 | GM17199 | |
| 3DL3 | 3DL3*00104a | 3DL3*00101 | 281 CAC (H)=>CAT (H) | GU070841 | GM17150 |
| 3DL3*00905 | 3DL3*00901 | 118 ACG (T)=>ACT (T) | GU944891 | GM17156 | |
| 3DL3*01408 | 3DL3*01401 | 266 CAC (H)=>CAT (H) | GU944892 | GM17162 | |
| 3DL3*01802 | 3DL3*01801 | 2 GTA (V)=>GTG (V), 35 AAC (N)=>AAT (N), 302 CAC (H)=>CAT (H) | GU944886 | GM17117 | |
| 3DL3*041a | 3DL3*00901 | 327 GCC (A) => CCC (P), 352 GAA (E)=>GAT (D) | GU070842 | GM17181 | |
| 3DL3*049 | 3DL3*00801 | 327 GCC (A) =>CCC (P), 352 GAA (E)=>GAT (D) | GU944881 | GM17105 | |
| 3DL3*050 | 3DL3*01403 | 292 GTT (V)=>ATT (I) | GU944882 | GM17107 | |
| 3DL3*051 | 3DL3*00202 | 35 AAT (N)=>AAA (K) | GU944885 | GM17117 | |
| 3DL3*052 | 3DL3*00901 | 86 TCG (S)=>CCG (P) | GU944887 | GM17120 | |
| 3DL3*053 | 3DL3*00201 | 292 GTT (V)=>ATT (I) | GU944888 | GM17126 | |
| 3DL3*054 | 3DL3*00901 | 113 GTG (V) =>ATG (M) | GU944890 | GM17141 | |
| 3DL3*055 | 3DL3*005 | 56 CGG (R)=>CAG (Q) | GU944893 | GM17171 |
a
Novel alleles are defined as the first description of the allele in the IPD-KIR database. Also included are alleles whose sequences are not reported in the IPD-KIR database release 2.3.0; our submission of the sequences of these alleles was designated as confirmatory by the WHO Committee for Factors of the HLA System.
b
Confirmatory allele.