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. 1982 Nov;38(2):408–412. doi: 10.1128/iai.38.2.408-412.1982

Synergism between immunosuppressive agents and uremia?

T E Miller, D J Ormrod, D M Wilson
PMCID: PMC347753  PMID: 7141702

Abstract

The susceptibility of uremic patients to infectious disease has been widely reported, but the host immune factors associated with the increased incidence of infection have not been clearly defined. In this study, the possibility of synergism between biologically active components that accumulate in uremia and immunosuppressive drugs used in the course of management was investigated. An animal model of chronic stable uremia was used in these experiments to assess the effect of cyclophosphamide, methotrexate, and azathioprine on antibody response in the uremic host. Chronic uremia did not affect the immunosuppressive activity of cyclophosphamide, methotrexate, or azathioprine, and synergism between these agents and uremic components is unlikely to complicate further the immune status of the host in renal failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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