Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1982 Nov;38(2):471–475. doi: 10.1128/iai.38.2.471-475.1982

Experimental cryptosporidiosis in laboratory mice.

D Sherwood, K W Angus, D R Snodgrass, S Tzipori
PMCID: PMC347763  PMID: 7141705

Abstract

Eight strains of laboratory mice were susceptible to subclinical infections with Cryptosporidium sp. at 1 to 4 days of age, but only a transient infection could be established at 21 days of age or older. Immunosuppression of 21-day-old mice failed to render them more susceptible to infection. Laboratory storage conditions for Cryptosporidium sp. were investigated by titration in 1- to 4-day-old mice. Storage by freezing with a variety of cryoprotectants was unsuccessful, but storage at 4 degrees C in phosphate-buffered saline or 2.5% potassium dichromate was possible for 4 to 6 months.

Full text

PDF
471

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERENBAUM M. C., BROWN I. N. DOSE-RESPONSE RELATIONSHIPS FOR AGENTS INHIBITING THE IMMUNE RESPONSE. Immunology. 1964 Jan;7:65–71. [PMC free article] [PubMed] [Google Scholar]
  2. BOVARNICK M. R., MILLER J. C., SNYDER J. C. The influence of certain salts, amino acids, sugars, and proteins on the stability of rickettsiae. J Bacteriol. 1950 Apr;59(4):509–522. doi: 10.1128/jb.59.4.509-522.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bird R. G., Smith M. D. Cryptosporidiosis in man: parasite life cycle and fine structural pathology. J Pathol. 1980 Nov;132(3):217–233. doi: 10.1002/path.1711320304. [DOI] [PubMed] [Google Scholar]
  4. CLARKE D. H., CASALS J. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. Am J Trop Med Hyg. 1958 Sep;7(5):561–573. doi: 10.4269/ajtmh.1958.7.561. [DOI] [PubMed] [Google Scholar]
  5. EYLES D. E., COLEMAN N., CAVANAUGH D. J. Preservation of Toxoplasma gondii by freezing. J Parasitol. 1956 Aug;42(4 SECTION):408–413. [PubMed] [Google Scholar]
  6. Hampton J. C., Rosario B. The attachment of protozoan parasites to intestinalepithelial cells of the mouse. J Parasitol. 1966 Oct;52(5):939–949. [PubMed] [Google Scholar]
  7. Heine J., Boch J. Kryptosporidien-Infektionen beim Kalb. Nachweis, Vorkommen und experimentelle Ubertragung. Berl Munch Tierarztl Wochenschr. 1981 Aug 1;94(15):289–292. [PubMed] [Google Scholar]
  8. Moon H. W., Bemrick W. J. Fecal transmission of calf cryptosporidia between calves and pigs. Vet Pathol. 1981 Mar;18(2):248–255. doi: 10.1177/030098588101800213. [DOI] [PubMed] [Google Scholar]
  9. Moon H. W., McClurkin A. W., Isaacson R. E., Pohlenz J., Skartvedt S. M., Gillette K. G., Baetz A. L. Pathogenic relationships of rotavirus, Escherichia coli, and other agents in mixed infections in calves. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):577–583. [PubMed] [Google Scholar]
  10. Morin M., Larivière S., Lallier R. Pathological and microbiological observations made on spontaneous cases of acute neonatal calf diarrhea. Can J Comp Med. 1976 Jul;40(3):228–240. [PMC free article] [PubMed] [Google Scholar]
  11. Reese N. C., Current W. L., Ernst J. V., Bailey W. S. Cryptosporidiosis of man and calf: a case report and results of experimental infections in mice and rats. Am J Trop Med Hyg. 1982 Mar;31(2):226–229. doi: 10.4269/ajtmh.1982.31.226. [DOI] [PubMed] [Google Scholar]
  12. Tzipori S., Angus K. W., Campbell I., Clerihew L. W. Diarrhea due to Cryptosporidium infection in artificially reared lambs. J Clin Microbiol. 1981 Jul;14(1):100–105. doi: 10.1128/jcm.14.1.100-105.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tzipori S., Angus K. W., Campbell I., Gray E. W. Cryptosporidium: evidence for a single-species genus. Infect Immun. 1980 Dec;30(3):884–886. doi: 10.1128/iai.30.3.884-886.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tzipori S., Angus K. W., Campbell I., Sherwood D. Diarrhea in young red deer associated with infection with Cryptosporidium. J Infect Dis. 1981 Aug;144(2):170–175. doi: 10.1093/infdis/144.2.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tzipori S., Angus K. W., Gray E. W., Campbell I., Allan F. Diarrhea in lambs experimentally infected with Cryptosporidium isolated from calves. Am J Vet Res. 1981 Aug;42(8):1400–1404. [PubMed] [Google Scholar]
  16. Tzipori S., Angus K. W., Gray E. W., Campbell I. Vomiting and diarrhea associated with cryptosporidial infection. N Engl J Med. 1980 Oct 2;303(14):818–818. [PubMed] [Google Scholar]
  17. Tzipori S., Campbell I., Sherwood D., Snodgrass D. R., Whitelaw A. An outbreak of calf diarrhoea attributed to cryptosporidial infection. Vet Rec. 1980 Dec 20;107(25-26):579–580. [PubMed] [Google Scholar]
  18. Tzipori S., McCartney E., Lawson G. H., Rowland A. C., Campbell I. Experimental infection of piglets with cryptosporidium. Res Vet Sci. 1981 Nov;31(3):358–368. [PubMed] [Google Scholar]
  19. Tzipori S., Sherwood D., Angus K. W., Campbell I., Gordon M. Diarrhea in lambs: experimental infections with enterotoxigenic Escherichia coli, rotavirus, and Cryptosporidium sp. Infect Immun. 1981 Aug;33(2):401–406. doi: 10.1128/iai.33.2.401-406.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vetterling J. M., Jervis H. R., Merrill T. G., Sprinz H. Cryptosporidium wrairi sp. n. from the guinea pig Cavia porcellus, with an emendation of the genus. J Protozool. 1971 May;18(2):243–247. doi: 10.1111/j.1550-7408.1971.tb03315.x. [DOI] [PubMed] [Google Scholar]
  21. Vetterling J. M., Takeuchi A., Madden P. A. Ultrastructure of Cryptosporidium wrairi from the guinea pig. J Protozool. 1971 May;18(2):248–260. doi: 10.1111/j.1550-7408.1971.tb03316.x. [DOI] [PubMed] [Google Scholar]
  22. Weisburger W. R., Hutcheon D. F., Yardley J. H., Roche J. C., Hillis W. D., Charache P. Cryptosporidiosis in an immunosuppressed renal-transplant recipient with IgA deficiency. Am J Clin Pathol. 1979 Sep;72(3):473–478. doi: 10.1093/ajcp/72.3.473. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES