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. 1982 Nov;38(2):731–738. doi: 10.1128/iai.38.2.731-738.1982

Pathogenicity of avian reoviruses: examination of six isolates and a vaccine strain.

V Gouvea, T J Schnitzer
PMCID: PMC347799  PMID: 6292109

Abstract

Six avian reovirus isolates and a vaccine reovirus strain were compared for invasiveness, virulence, and pathological characteristics upon infection of day-old specific-pathogen-free chicks by the footpad, subcutaneous, and oral routes of inoculation. No significant differences were noted regarding the ability of individual isolates to infect target tissues. However, virulence (measured as the 50% lethal dose) among the isolates varied markedly from 2 x 10(5) to less than 10 PFU per chick for the most virulent isolate; between the parental wild-type virus and the derivative vaccine virus strain, a million-fold (10(6)) difference in virulence was demonstrated. All strains revealed, with considerable variation, arthrogenic potential.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bains B. S., MacKenzie M., Spradbrow P. B. Reovirus-associated mortality in broiler chickens. Avian Dis. 1974 Jul;18(3):472–476. [PubMed] [Google Scholar]
  2. Deshmukh D. R., Pomeroy B. S. Avian reoviruses. I. Isolation and serological characterization. Avian Dis. 1969 May;13(2):239–243. [PubMed] [Google Scholar]
  3. Fahey J. E., Crawley J. F. Studies On Chronic Respiratory Disease Of Chickens II. Isolation of A Virus. Can J Comp Med Vet Sci. 1954 Jan;18(1):13–21. [PMC free article] [PubMed] [Google Scholar]
  4. Gershowitz A., Wooley R. E. Characterization of two reoviruses isolated from turkeys with infectious enteritis. Avian Dis. 1973 Apr-Jun;17(2):406–414. [PubMed] [Google Scholar]
  5. Gouvea V. S., Schnitzer T. J. Polymorphism of the genomic RNAs among the avian reoviruses. J Gen Virol. 1982 Jul;61(Pt 50):87–91. doi: 10.1099/0022-1317-61-1-87. [DOI] [PubMed] [Google Scholar]
  6. Johnson D. C., Van der Heide L. Incidence of tenosynovitis in Maine broilers. Avian Dis. 1971 Oct-Dec;15(4):829–834. [PubMed] [Google Scholar]
  7. Jones R. C. Reoviruses from chickens with hydropericardium. Vet Rec. 1976 Dec 4;99(23):458–458. doi: 10.1136/vr.99.23.458-a. [DOI] [PubMed] [Google Scholar]
  8. Mustaffa-Babjee A., Spradbrow P. B., Omar A. R. Characterization of an avian reovirus isolated in Queensland. J Comp Pathol. 1973 Jul;83(3):387–400. doi: 10.1016/0021-9975(73)90063-7. [DOI] [PubMed] [Google Scholar]
  9. OLSON N. O. Transmissible synovitis of poultry. Lab Invest. 1959 Nov-Dec;8:1384–1393. [PubMed] [Google Scholar]
  10. Olson N. O., Khan M. A. The effect of intranasal exposure of chickens to the Fahey-Crawley virus on the development of synovial lesions. Avian Dis. 1972 Oct-Dec;16(5):1073–1078. [PubMed] [Google Scholar]
  11. Olson N. O., Solomon D. P. A natural outbreak of synovitis caused by the viral arthritis agent. Avian Dis. 1968 May;12(2):311–316. [PubMed] [Google Scholar]
  12. Sahu S. P., Olson N. O. Comparison of the characteristics of avian reoviruses isolated from the digestive and respiratory tract, with viruses isolated from the synovia. Am J Vet Res. 1975 Jun;36(6):847–850. [PubMed] [Google Scholar]
  13. Sahu S. P., Olson N. O., Townsend R. W. Characterization of avian reoviruses isolated from the synovia and breast blister. Avian Dis. 1979 Oct-Dec;23(4):896–903. [PubMed] [Google Scholar]
  14. Weiner H. L., Drayna D., Averill D. R., Jr, Fields B. N. Molecular basis of reovirus virulence: role of the S1 gene. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5744–5748. doi: 10.1073/pnas.74.12.5744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wood G. W., Nicholas R. A., Hebert C. N., Thornton D. H. Serological comparisons of avian reoviruses. J Comp Pathol. 1980 Jan;90(1):29–38. doi: 10.1016/0021-9975(80)90025-0. [DOI] [PubMed] [Google Scholar]
  16. Wood G. W., Thornton D. H. Experimental infection of broiler chickens with an avian reovirus. J Comp Pathol. 1981 Jan;91(1):69–76. doi: 10.1016/0021-9975(81)90046-3. [DOI] [PubMed] [Google Scholar]
  17. van der Heide L., Kalbac M., Hall W. C. Infectious tenosynovitis (viral arthritis): influence of maternal antibodies on the development of tenosynovitis lesions after experimental infection by day-old chickens with tenosynovitis virus. Avian Dis. 1976 Oct-Dec;20(4):641–648. [PubMed] [Google Scholar]
  18. van der Heide L., Kalbac M. Infectious tenosynovitis (viral arthritis): characterization of a Connecticut viral isolant as a reovirus and evidence of viral egg transmission by reovirus-infected broiler breeders. Avian Dis. 1975 Oct-Dec;19(4):683–688. [PubMed] [Google Scholar]

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