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. 1982 Nov;38(2):788–790. doi: 10.1128/iai.38.2.788-790.1982

Mammary gland contamination as a means of establishing long-term gastrointestinal colonization of infant mice with Candida albicans.

R F Hector, J E Domer
PMCID: PMC347808  PMID: 6754622

Abstract

Infant outbred CD-1 mice were infected intragastrically with Candida albicans by inoculating the mammary glands of the lactating mothers with viable blastospores and allowing the infants to suckle. Levels of colonization were determined by quantitative cultures of stomachs and selected organs at various intervals up to 6 weeks after infection. The results demonstrate that a high percentage of infant mice can be colonized in this manner and that the colonization is of long duration. Although systemic spread of the yeast to other visceral organs did occur, the numbers of yeasts recovered were minimal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DeMaria A., Buckley H., von Lichtenberg F. Gastrointestinal candidiasis in rats treated with antibiotics, cortisone, and azathioprine. Infect Immun. 1976 Jun;13(6):1761–1770. doi: 10.1128/iai.13.6.1761-1770.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Field L. H., Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Persistence and spread of Candida albicans after intragastric inoculation of infant mice. Infect Immun. 1981 Feb;31(2):783–791. doi: 10.1128/iai.31.2.783-791.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Helstrom P. B., Balish E. Effect of oral tetracycline, the microbial flora, and the athymic state on gastrointestinal colonization and infection of BALB/c mice with Candida albicans. Infect Immun. 1979 Mar;23(3):764–774. doi: 10.1128/iai.23.3.764-774.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Krause W., Matheis H., Wulf K. Fungaemia and funguria after oral administration of Candida albicans. Lancet. 1969 Mar 22;1(7595):598–599. doi: 10.1016/s0140-6736(69)91534-7. [DOI] [PubMed] [Google Scholar]
  5. Meunier-Carpentier F., Kiehn T. E., Armstrong D. Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality. Am J Med. 1981 Sep;71(3):363–370. doi: 10.1016/0002-9343(81)90162-5. [DOI] [PubMed] [Google Scholar]
  6. Pappagianis D., Collins M. S., Hector R., Remington J. Development of resistance to amphotericin B in Candida lusitaniae infecting a human. Antimicrob Agents Chemother. 1979 Aug;16(2):123–126. doi: 10.1128/aac.16.2.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Parker J. C., Jr, McCloskey J. J., Knauer K. A. Pathobiologic features of human candidiasis. A common deep mycosis of the brain, heart and kidney in the altered host. Am J Clin Pathol. 1976 Jun;65(6):991–1000. doi: 10.1093/ajcp/65.6.991. [DOI] [PubMed] [Google Scholar]
  8. Parker J. C., Jr The potentially lethal problem of cardiac candidosis. Am J Clin Pathol. 1980 Mar;73(3):356–361. doi: 10.1093/ajcp/73.3.356. [DOI] [PubMed] [Google Scholar]
  9. Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge. Infect Immun. 1979 Aug;25(2):702–707. doi: 10.1128/iai.25.2.702-707.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Restrepo-Moreno A., Schneidau J. D., Jr Nature of the skin-reactive principle in culture filtrates prepared from Paracoccidioides brasiliensis. J Bacteriol. 1967 Jun;93(6):1741–1748. doi: 10.1128/jb.93.6.1741-1748.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Savage D. C. Microbial interference between indigenous yeast and lactobacilli in the rodent stomach. J Bacteriol. 1969 Jun;98(3):1278–1283. doi: 10.1128/jb.98.3.1278-1283.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Singer C., Kaplan M. H., Armstrong D. Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med. 1977 May;62(5):731–742. doi: 10.1016/0002-9343(77)90876-2. [DOI] [PubMed] [Google Scholar]
  13. Turner J. R., Butler T. F., Johnson M. E., Gordee R. S. Colonization of the intestinal tract of conventional mice with Candida albicans and treatment with antifungal agents. Antimicrob Agents Chemother. 1976 May;9(5):787–792. doi: 10.1128/aac.9.5.787. [DOI] [PMC free article] [PubMed] [Google Scholar]

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