SPI1
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Assembly of needle and secretion of effector proteins
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SpaO, InvJ, InvG, PrgI, PrgJ, PrgK, SipB, SipC
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Actin cytoskeletal rearrangement via Rho GTPases and tight junction disruption
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SopE, SopE2, SopB (or SigD)
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Actin polymerization by decrease in critical concentration
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SipA
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Modulation of actin cytoskeleton by actin nucleation
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SipC (or SspC)
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Regaining of cytoskeleton by reversing action of SopE, SopE2 and SopB
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SptP
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Fluid accumulation in intestine
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SopA, SopD, SopB
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Modulation of chloride channel to induce diarrhea
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SopB, SopE
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Inhibition of NFkappaB activity and IL-8 secretion
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AvrA, SspH1
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Transmigration of polymorphonuclear leukocytes
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SipA, SopA
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Activation of caspase 1 and autophagy in macrophages
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SipB (or SspB)
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SPI2
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Needle assembly
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SpiB, SpiC, SpiD etc. (also known as Ssa genes)
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Effector protein translocation
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SseB, SseC, SseD
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Interference with endosome trafficking
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SpiC
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Maintenance of SCV integrity
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SifA
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Salmonella induced filament (Sif) formation and microtubule bundling
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SifA, SseF, Sseg, SopD2, PipB2
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Inhibition of actin polymerization
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SspH2
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Downregulation of Sif formation
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SpvB
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Host cell dissemination
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SseI
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| Anaerobic respiration by reducing tetrathionate |
TtrABC, TtrRS |
