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. 1982 Dec;38(3):925–931. doi: 10.1128/iai.38.3.925-931.1982

Antigenic determinant of the Lancefield group H antigen of Streptococcus sanguis.

B Rosan, L Argenbright
PMCID: PMC347838  PMID: 6185428

Abstract

Previous studies indicated that the teichoic acid isolated from strains of Streptococcus sanguis was group specific and defined the Lancefield group H streptococci. To determine the specific antigenic determinants, the antigen was extracted from a group H streptococcus (ATCC 903) by the phenol-water method and purified by column chromatography. The isolated antigen had a glycerol/phosphate/glucose molar ratio of 1:0.9:0.3; the lipid concentration was 7.6% of its dry weight. No nucleic acids were detected, and amino acids constituted approximately 2% of the dry weight. The minimum concentration of antigen required to sensitize erythrocytes for hemagglutination with a 1:1,000 dilution of either group H antiserum or antiteichoic acid serum was 0.02 microgram/ml. Hemagglutination inhibition studies suggested that the major antigenic determinant consisted of an alpha-glucose linked to the glycerol phosphate backbone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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