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. 1982 Dec;38(3):948–952. doi: 10.1128/iai.38.3.948-952.1982

Innate resistance of mice to Salmonella typhi infection.

A D O'Brien
PMCID: PMC347841  PMID: 7152679

Abstract

The basis for the natural resistance of mice to Salmonella typhi was examined. In contrast to Salmonella typhimurium, the virulence of S. typhi for mice was independent of the mouse strain and was not affected by inactivation of murine macrophages with silica. However, mice were more susceptible to S. typhi when given iron alone or iron and an iron chelator. The results suggest that the failure of S. typhi to undergo net growth in murine tissues reflects an inability of the bacterium to multiply rather than rapid killing by resident macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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