Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1982 Dec;38(3):1291–1295. doi: 10.1128/iai.38.3.1291-1295.1982

Nocardia brasiliensis: mycetoma induction and growth cycle.

C Conde, E I Melendro, M Fresán, L Ortiz-Ortiz
PMCID: PMC347888  PMID: 7152671

Abstract

The capacity of Nocardia brasiliensis to induce mycetoma in BALB/c mice in the absence of adjuvants was studied. Whether the virulence of N. brasiliensis varied in the different phases of its growth cycle was also determined. The results showed that N. brasiliensis suspended in 0.15 M NaCl and injected into the footpads of mice were able to induce mycetoma after only 14 days of infection, as evidenced by histological studies. Data are also presented indicating that the virulence of N. brasiliensis did not vary during the different phases of its growth curve. The differences in virulence reported between N. brasiliensis and other nocardiae are discussed and explained in terms of several variables in the experimental designs used: among these variables are mouse genotype, route of inoculation, and model for determining virulence.

Full text

PDF
1291

Images in this article

1292Image
on p.1292

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaman B. L., Maslan S. Effect of cyclophosphamide on experimental Nocardia asteroides infection in mice. Infect Immun. 1977 Jun;16(3):995–1004. doi: 10.1128/iai.16.3.995-1004.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman B. L., Maslan S., Scates S., Rosen J. Effect of route on inoculation on host resistance to Nocardia. Infect Immun. 1980 Apr;28(1):185–189. doi: 10.1128/iai.28.1.185-189.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beaman B. L., Maslan S. Virulence of Nocardia asteroides during its growth cycle. Infect Immun. 1978 Apr;20(1):290–295. doi: 10.1128/iai.20.1.290-295.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beaman B. L., Scates S. M. Role of L-forms of Nocardia caviae in the development of chronic mycetomas in normal and immunodeficient murine models. Infect Immun. 1981 Sep;33(3):893–907. doi: 10.1128/iai.33.3.893-907.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Folb P. I., Jaffe R., Altmann G. Nocardia asteroides and Nocardia brasiliensis infections in mice. Infect Immun. 1976 May;13(5):1490–1496. doi: 10.1128/iai.13.5.1490-1496.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Folb P. I., Timme A., Horowitz A. Nocardia infections in congenitally athymic (nude) mice and in other inbred mouse strains. Infect Immun. 1977 Nov;18(2):459–466. doi: 10.1128/iai.18.2.459-466.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GONZALEZ-OCHOA A. Mycetoma by Nocardia brasiliensis. Isolation of the agent from soils. Rev Inst Salubr Enferm Trop. 1962 Jun;22:15–24. [PubMed] [Google Scholar]
  8. Gonzalez Ochoa A. Virulence of nocardiae. Can J Microbiol. 1973 Aug;19(8):901–904. doi: 10.1139/m73-144. [DOI] [PubMed] [Google Scholar]
  9. González-Ochoa A. Geografía de las micosis profundas. Rev Invest Salud Publica. 1975 Jan-Mar;35(1):85–96. [PubMed] [Google Scholar]
  10. Krick J. A., Remington J. S. Resistance to infection with Nocardia asteroides. J Infect Dis. 1975 Jun;131(6):665–672. doi: 10.1093/infdis/131.6.665. [DOI] [PubMed] [Google Scholar]
  11. Mariat F., Destombes P., Segretain G. The mycetomas: clinical features, pathology, etiology and epidemiology. Contrib Microbiol Immunol. 1977;4:1–39. [PubMed] [Google Scholar]
  12. Melendro E. I., Contreras M. F., Ximénez C., García-Maynez A. M., Ortiz-Ortiz L. Changes in host resistance caused by Nocardia brasiliensis in mice: cross-protection against Listeria monocytogenes. Int Arch Allergy Appl Immunol. 1978;57(1):74–81. doi: 10.1159/000232086. [DOI] [PubMed] [Google Scholar]
  13. Ximénez C., Melendro E. I., González-Mendoza A., García A. M., Martínez A., Ortiz-Ortiz L. Resistance to Nocardia brasiliensis infection in mice immunized with either Nocardia or BCG. Mycopathologia. 1980 Mar 17;70(2):117–122. doi: 10.1007/BF00443077. [DOI] [PubMed] [Google Scholar]
  14. Zlotnik H., Buckley H. R. Experimental production of actinomycetoma in BALB/c mice. Infect Immun. 1980 Sep;29(3):1141–1145. doi: 10.1128/iai.29.3.1141-1145.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES