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. 1983 Jan;39(1):233–238. doi: 10.1128/iai.39.1.233-238.1983

Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM197

Porter Anderson 1
PMCID: PMC347931  PMID: 6600444

Abstract

Oligosaccharides were made from Haemophilus influenzae type b capsular polysaccharide and conjugated to CRM197 by reductive amination. Conjugates were made with a range of lengths and multiplicities of saccharide chains. All elicited a strongly enhanced anti-H. influenzae type b capsular polysaccharide response when injected into weanling rabbits. One series of conjugates also elicited antibodies to diphtheria toxin.

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Selected References

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