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. 1983 Jan;39(1):473–475. doi: 10.1128/iai.39.1.473-475.1983

Coccidioides immitis Vaccine: Potential of an Alkali-Soluble, Water-Soluble Cell Wall Antigen

Grace Lecara 1, Rebecca A Cox 2, Russell B Simpson 1
PMCID: PMC347967  PMID: 6822433

Abstract

C-ASWS-M, the alkali-soluble, water-soluble cell wall antigen of Coccidioides immitis mycelia, was evaluated for its vaccine potential in mice. Vaccination with 0.5-, 1.5-, or 3-mg doses of C-ASWS-M in complete Freund adjuvant provided a significant level of protection against intraperitoneal challenge with 1,500 arthroconidia (P < 0.0001 with each dose). Vaccination with 1 mg of C-ASWS-M protected mice against intranasal challenge with 50 (P < 0.05) and 500 (P < 0.01) arthroconidia, but not against intranasal challenge with 1,500 arthroconidia (P > 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cox R. A., Brummer E., Lecara G. In vitro lymphocyte responses of coccidioidin skin test-positive and -negative persons to coccidioidin, spherulin, and a coccidioides cell wall antigen. Infect Immun. 1977 Mar;15(3):751–755. doi: 10.1128/iai.15.3.751-755.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. KONG Y. C., LEVINE H. B., SMITH C. E. Immunogenic properties of nondisrupted and disrupted spherules of Coccidioides immitis in mice. Sabouraudia. 1963 Feb;2:131–142. [PubMed] [Google Scholar]
  3. Kong Y. C., Levine H. B. Experimentally induced immunity in the mycoses. Bacteriol Rev. 1967 Mar;31(1):35–53. doi: 10.1128/br.31.1.35-53.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kong Y. M., Savage D. C., Levine H. B. Enhancement of immune responses in mice by a booster injection of Coccidioides spherules. J Immunol. 1965 Dec;95(6):1048–1056. [PubMed] [Google Scholar]
  5. LEVINE H. B., COBB J. M., SMITH C. E. Immunity to coccidioi-domycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines. Trans N Y Acad Sci. 1960 Apr;22:436–449. doi: 10.1111/j.2164-0947.1960.tb00711.x. [DOI] [PubMed] [Google Scholar]
  6. LEVINE H. B., COBB J. M., SMITH C. E. Immunogenicity of spherule-endospore vaccines of Coccidioides immitis for mice. J Immunol. 1961 Aug;87:218–227. [PubMed] [Google Scholar]
  7. LEVINE H. B., KONG Y. C., SMITH C. IMMUNIZATION OF MICE TO COCCIDIOIDES IMMITIS: DOSE, REGIMEN AND SPHERULATION STAGE OF KILLED SPHERULE VACCINES. J Immunol. 1965 Jan;94:132–142. [PubMed] [Google Scholar]
  8. Pappagianis D., Hector R., Levine H. B., Collins M. S. Immunization of mice against coccidioidomycosis with a subcellular vaccine. Infect Immun. 1979 Jul;25(1):440–445. doi: 10.1128/iai.25.1.440-445.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ward E. R., Jr, Cox R. A., Schmitt J. A., Jr, Huppert M., Sun S. H. Delayed-type hypersensitivity responses to a cell wall fraction of the mycelial phase of Coccidioides immitis. Infect Immun. 1975 Nov;12(5):1093–1097. doi: 10.1128/iai.12.5.1093-1097.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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