Abstract
Acyclovir had a dose-dependent, mild, but significant, inhibitory effect on interferon-stimulated human antiviral natural killer cytotoxicity in vitro. In a murine model of neonatal herpes simplex virus infection, acyclovir significantly (P < 0.05) increased survival afforded by the injection of human interferon and human mononuclear leukocytes from 67.8 to 88.6%.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Herberman R. B., Ortaldo J. R. Natural killer cells: their roles in defenses against disease. Science. 1981 Oct 2;214(4516):24–30. doi: 10.1126/science.7025208. [DOI] [PubMed] [Google Scholar]
- Hirsch M. S., Swartz M. N. Drug therapy: antiviral agents (second of two parts). N Engl J Med. 1980 Apr 24;302(17):949–953. doi: 10.1056/NEJM198004243021705. [DOI] [PubMed] [Google Scholar]
- Kohl S., Frazier J. J., Greenberg S. B., Pickering L. K., Loo L. S. Interferon induction of natural killer cytotoxicity in human neonates. J Pediatr. 1981 Mar;98(3):379–384. doi: 10.1016/s0022-3476(81)80699-3. [DOI] [PubMed] [Google Scholar]
- Kohl S., Loo L. S., Greenberg S. B. Protection of newborn mice from a lethal herpes simplex virus infection by human interferon, antibody, and leukocytes. J Immunol. 1982 Mar;128(3):1107–1111. [PubMed] [Google Scholar]
- Kohl S., Loo L. S. Ontogeny of murine cellular cytotoxicity to herpes simplex virus-infected cells. Infect Immun. 1980 Dec;30(3):847–850. doi: 10.1128/iai.30.3.847-850.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whitley R. J., Nahmias A. J., Soong S. J., Galasso G. G., Fleming C. L., Alford C. A. Vidarabine therapy of neonatal herpes simplex virus infection. Pediatrics. 1980 Oct;66(4):495–501. [PubMed] [Google Scholar]