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. 1983 Jan;39(1):487–489. doi: 10.1128/iai.39.1.487-489.1983

Effect of Oxygen-Dependent Antimicrobial Systems on Legionella pneumophila

Janis E Lochner 1,2, Richard L Friedman 1, Robert H Bigley 2, Barbara H Iglewski 1
PMCID: PMC347971  PMID: 6295960

Abstract

Legionella pneumophila was susceptible to the antimicrobial action of oxygen metabolites generated by both the myeloperoxidase-H2O2-halide and the xanthine oxidase systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beauchamp C., Fridovich I. A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem. 1970 Sep 25;245(18):4641–4646. [PubMed] [Google Scholar]
  2. Blackmon J. A., Hicklin M. D., Chandler F. W. Legionnaires' disease. Pathological and historical aspects of a 'new' disease. Arch Pathol Lab Med. 1978 Jul;102(7):337–343. [PubMed] [Google Scholar]
  3. Buege J. A., Aust S. D. Lactoperoxidase-catalyzed lipid peroxidation of microsomal and artificial membranes. Biochim Biophys Acta. 1976 Aug 24;444(1):192–201. doi: 10.1016/0304-4165(76)90236-1. [DOI] [PubMed] [Google Scholar]
  4. DUBOS R. J. Effect of ketone bodies and other metabolites on the survival and multiplication of staphylococci and tubercle bacilli. J Exp Med. 1953 Aug;98(2):145–155. doi: 10.1084/jem.98.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fridovich I. Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J Biol Chem. 1970 Aug 25;245(16):4053–4057. [PubMed] [Google Scholar]
  6. Friedman R. L., Iglewski B. H., Miller R. D. Identification of a cytotoxin produced by Legionella pneumophila. Infect Immun. 1980 Jul;29(1):271–274. doi: 10.1128/iai.29.1.271-274.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Friedman R. L., Lochner J. E., Bigley R. H., Iglewski B. H. The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes. J Infect Dis. 1982 Sep;146(3):328–334. doi: 10.1093/infdis/146.3.328. [DOI] [PubMed] [Google Scholar]
  8. Horwitz M. A., Silverstein S. C. Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody, and complement. J Exp Med. 1981 Feb 1;153(2):386–397. doi: 10.1084/jem.153.2.386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Horwitz M. A., Silverstein S. C. Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication. J Exp Med. 1981 Feb 1;153(2):398–406. doi: 10.1084/jem.153.2.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnston R. B., Jr, Keele B. B., Jr, Misra H. P., Lehmeyer J. E., Webb L. S., Baehner R. L., RaJagopalan K. V. The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest. 1975 Jun;55(6):1357–1372. doi: 10.1172/JCI108055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kellogg E. W., 3rd, Fridovich I. Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem. 1975 Nov 25;250(22):8812–8817. [PubMed] [Google Scholar]
  12. Klebanoff S. J. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Semin Hematol. 1975 Apr;12(2):117–142. [PubMed] [Google Scholar]
  13. Klebanoff S. J., Hamon C. B. Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. J Reticuloendothel Soc. 1972 Aug;12(2):170–196. [PubMed] [Google Scholar]
  14. Klebanoff S. J. Iodination of bacteria: a bactericidal mechanism. J Exp Med. 1967 Dec 1;126(6):1063–1078. doi: 10.1084/jem.126.6.1063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McDade J. E., Shepard C. C. Virulent to avirulent conversion of Legionnaires' disease bacterium (Legionella pneumophila)--its effect on isolation techniques. J Infect Dis. 1979 Jun;139(6):707–711. doi: 10.1093/infdis/139.6.707. [DOI] [PubMed] [Google Scholar]
  16. Selvaraj R. J., Paul B. B., Strauss R. R., Jacobs A. A., Sbarra A. J. Oxidative peptide cleavage and decarboxylation by the MPO-H2O2-Cl- antimicrobial system. Infect Immun. 1974 Feb;9(2):255–260. doi: 10.1128/iai.9.2.255-260.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Winn W. C., Jr, Glavin F. L., Perl D. P., Keller J. L., Andres T. L., Brown T. M., Coffin C. M., Sensecqua J. E., Roman L. N., Craighead J. E. The pathology of Legionnaires' disease. Fourteen fatal cases from the 1977 outbreak in Vermont. Arch Pathol Lab Med. 1978 Jul;102(7):344–350. [PubMed] [Google Scholar]
  18. Winn W. C., Jr, Myerowitz R. L. The pathology of the Legionella pneumonias. A review of 74 cases and the literature. Hum Pathol. 1981 May;12(5):401–422. doi: 10.1016/s0046-8177(81)80021-4. [DOI] [PubMed] [Google Scholar]
  19. Zeya H. I., Spitznagel J. K. Antimicrobial specificity of leukocyte lysosomal cationic proteins. Science. 1966 Nov 25;154(3752):1049–1051. doi: 10.1126/science.154.3752.1049. [DOI] [PubMed] [Google Scholar]

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