Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1983 Feb;39(2):575–579. doi: 10.1128/iai.39.2.575-579.1983

Tumor-dependent resistance of rat peritoneal macrophages to herpes simplex virus.

L Bonina, D Iannello, R Merendino, A Arena, P Mastroeni
PMCID: PMC347990  PMID: 6299945

Abstract

By their position at sites of initial infection and their wide distribution in major organs of the body, macrophages may be decisive in determining the susceptibility or resistance of the host to virus infection. Macrophage restriction of virus replication has been shown to be closely related to virus strains or virus types and to the age of the infected host. We report the effects of the development of a solid tumor in rats on intrinsic in vitro macrophage activity against herpes simplex virus type 1. The results obtained with the infectious center assays and the analysis of single-cycle growth curves of herpes simplex virus type 1 in macrophages obtained from normal and tumor-bearing rats showed a depression of antiviral activity of macrophages from tumor-bearing rats. The possibility of immunomodulation by bacterial adjuvants on tumor-bearing rats and the effects on the antiviral activity of peritoneal macrophages were furthermore demonstrated.

Full text

PDF
575

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANG F. B., LUTTRELL C. N. Factors in the pathogenesis of virus diseases. Adv Virus Res. 1961;8:199–244. doi: 10.1016/s0065-3527(08)60686-7. [DOI] [PubMed] [Google Scholar]
  2. Bang F. B., Warwick A. MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065–1075. doi: 10.1073/pnas.46.8.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cerottini J. C., Brunner K. T. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974;18:67–132. doi: 10.1016/s0065-2776(08)60308-9. [DOI] [PubMed] [Google Scholar]
  4. Dulbecco R. Production of Plaques in Monolayer Tissue Cultures by Single Particles of an Animal Virus. Proc Natl Acad Sci U S A. 1952 Aug;38(8):747–752. doi: 10.1073/pnas.38.8.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GOODMAN G. T., KOPROWSKI H. Macrophages as a cellular expression of inherited natural resistance. Proc Natl Acad Sci U S A. 1962 Feb;48:160–165. doi: 10.1073/pnas.48.2.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gresser I., Lang D. J. Relationships between viruses and leucocytes. Prog Med Virol. 1966;8:62–130. [PubMed] [Google Scholar]
  7. Hirsch M. S., Zisman B., Allison A. C. Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol. 1970 May;104(5):1160–1165. [PubMed] [Google Scholar]
  8. Iannello D., Bonina L., Delfino D. Selective depression of phagocytes intracellular killing activity. Adv Exp Med Biol. 1982;141:199–206. doi: 10.1007/978-1-4684-8088-7_21. [DOI] [PubMed] [Google Scholar]
  9. JOHNSON R. T. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE. J Exp Med. 1964 Sep 1;120:359–374. doi: 10.1084/jem.120.3.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KILBOURNE E. D., HORSFALL F. L., Jr Studies of herpes simplex virus in newborn mice. J Immunol. 1951 Oct;67(4):321–329. [PubMed] [Google Scholar]
  11. Kohn L. D., Isersky C., Zupnik J., Lenaers A., Lee G., Lapiére C. M. Calf tendon procollagen peptidase: its purification and endopeptidase mode of action. Proc Natl Acad Sci U S A. 1974 Jan;71(1):40–44. doi: 10.1073/pnas.71.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Levy M. H., Wheelock E. F. The role of macrophages in defense against neoplastic disease. Adv Cancer Res. 1974;20:131–163. doi: 10.1016/s0065-230x(08)60110-4. [DOI] [PubMed] [Google Scholar]
  13. MIMS C. A. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES. Bacteriol Rev. 1964 Mar;28:30–71. doi: 10.1128/br.28.1.30-71.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Meltzer M. S., Stevenson M. M. Macrophage function in tumor-bearing mice: dissociation of phagocytic and chemotactic responsiveness. Cell Immunol. 1978 Jan;35(1):99–111. doi: 10.1016/0008-8749(78)90130-2. [DOI] [PubMed] [Google Scholar]
  15. Mintz L., Drew W. L., Hoo R., Finley T. N. Age-dependent resistance of human alveolar macrophages to herpes simplex virus. Infect Immun. 1980 May;28(2):417–420. doi: 10.1128/iai.28.2.417-420.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. RUCHMAN I. Virulence of strains of herpes simplex virus for mice. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):649–652. doi: 10.3181/00379727-86-21191. [DOI] [PubMed] [Google Scholar]
  17. SIGEL M. M. Influence of age on susceptibility to virus infections with particular reference to laboratory animals. Annu Rev Microbiol. 1952;6:247–280. doi: 10.1146/annurev.mi.06.100152.001335. [DOI] [PubMed] [Google Scholar]
  18. Smith H. Mechanisms of virus pathogenicity. Bacteriol Rev. 1972 Sep;36(3):291–310. doi: 10.1128/br.36.3.291-310.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stevenson M. M., Meltzer M. S. Depressed chemotactic responses in vitro of peritoneal macrophages from tumor-bearing mice. J Natl Cancer Inst. 1976 Oct;57(4):847–852. doi: 10.1093/jnci/57.4.847. [DOI] [PubMed] [Google Scholar]
  20. Zisman B., Hirsch M. S., Allison A. C. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J Immunol. 1970 May;104(5):1155–1159. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES