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. 1983 Feb;39(2):742–749. doi: 10.1128/iai.39.2.742-749.1983

Characteristics of Mononuclear Phagocytes Mediating Antilisterial Resistance in Splenectomized Mice

Carolynn Pietrangeli 1, King C Pang 1, Emil Skamene 1, Patricia A L Kongshavn 1
PMCID: PMC348012  PMID: 6299948

Abstract

The characteristics of mononuclear phagocytes mediating resistance to infection with Listeria monocytogenes during the early phase (up to 48 h) of the response were investigated in mice of the A strain that had undergone splenectomy. Although irradiation in the sham-operated host had no effect on its antilisterial response when administered immediately before infection, it markedly reduced the ability of the splenectomized host to resist listerial challenge. This effect of radiation was demonstrable in the high-dose range (600 r) and could not be reversed immediately by repopulation with 20 × 106 syngeneic nucleated bone marrow cells. Administration of silica 24 h before infection profoundly enhanced the growth of L. monocytogenes in the liver of splenectomized mice. Shielding of the liver, but not the bone marrow, protected the splenectomized host against the effects of radiation, indicating that the cell population responsible for mediating the enhanced antilisterial resistance resides in the liver. The enhanced antilisterial resistance of splenectomized mice was specifically because of the absence of the spleen and not merely because of the removal of a favorable replicating environment for listeria organisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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